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The Annals of Pharmacotherapy: Vol. 36, No. 4, pp. 631-633. DOI 10.1345/aph.1A262
© 2002 Harvey Whitney Books Company.
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Research Articles

Cross-sensitivity between paroxetine and sertraline

CA Warnock and AG Azadian

OBJECTIVE: To report a case of possible cross-sensitivity between selective serotonin-reuptake inhibitors (SSRIs). CASE SUMMARY: A 20-year-old Southeast Asian man developed a maculopapular rash soon after starting paroxetine. Following resolution of this rash, another skin reaction with the same distribution and appearance occurred after sertraline therapy was started. DISCUSSION: Cross-reactivity between drugs with similar structures has been reported; however, cross-reactivity among SSRI antidepressants is unexpected given their differences in chemical structure. CONCLUSIONS: The possibility of cross-reactivity between SSRI antidepressants should be considered by clinicians who wish to switch from one SSRI to another due to a dermatologic reaction.




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Copyright © 2002 by Harvey Whitney Books Company.