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The Annals of Pharmacotherapy: Vol. 37, No. 1, pp. 122-126. DOI 10.1345/aph.1C118
© 2003 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Chronic Metoclopramide Therapy for Diabetic Gastroparesis

Paul F Lata, PharmD

Clinical Pharmacist, Case Management Services, Bay Area Medical Center, Marinette, WI

Denise L Walbrandt Pigarelli, PharmD

Clinical Assistant Professor, University of Wisconsin–Madison School of Pharmacy; Clinical Pharmacist, William S Middleton Memorial Veterans Affairs Hospital, Madison, WI

Reprints: Paul F Lata PharmD, Case Management Services, Bay Area Medical Center, 3100 Shore Dr., Marinette, WI 54143-4242, FAX 715/735-8040, E-mail plata{at}bamc.org

OBJECTIVE: To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis.

DATA SOURCES: Medical literature was accessed through MEDLINE (1965 to October 2002) and PubMed (1965 to October 2002). Key search terms included metoclopramide; diabetic gastroparesis; and dyskinesia, drug induced.

DATA SYNTHESIS: Metoclopramide is often used for diabetic gastroparesis, despite the risk of tardive dyskinesia. Published information is limited regarding long-term efficacy and toxicity of metoclopramide. The literature was assessed concerning these topics.

CONCLUSIONS: Limited data do not provide sufficient evidence to conclude whether metoclopramide is efficacious for chronic use. Routine monitoring may mitigate the risk associated with metoclopramide therapy.

Key Words: diabetic gastroparesis, metoclopramide, tardive dyskinesia

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