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The Annals of Pharmacotherapy: Vol. 37, No. 10, pp. 1441-1443. DOI 10.1345/aph.1D058
© 2003 Harvey Whitney Books Company.
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Carbamazepine-Induced Pseudo Mycosis Fungoides

Ülker Gül, MD

Associate Professor, Chief of Department of Dermatology, Ministry of Health Oncology Education and Research Hospital

Arzu Kiliç, MD

Clinical Assistant, Department of Dermatology, Ministry of Health Oncology Education and Research Hospital, Ankara, Turkey

Ayse Dursun, MD

Professor, Department of Pathology, School of Medicine, Gazi University, Ankara

Reprints: Arzu Kiliç, Department of Dermatology, Ministry of Health Oncology Education and Research Hospital, Onur sokak. llke Apt. No:47/11, 06570, Anittepe, Ankara, Turkey, kilicarzu{at}hotmail.com

OBJECTIVE: To report a case of pseudo mycosis fungoides due to carbamazepine.

CASE SUMMARY: A 54-year-old man experienced a skin lesion resembling mycosis fungoides without any systemic symptoms or signs 2 months after he had begun carbamazepine treatment for his seizures. Skin-punch biopsy specimens revealed mycosis fungoides–like histopathologic appearance. After drug discontinuation, the patient experienced complete remission of the clinical and pathologic findings. This suggests a diagnosis of pseudo mycosis fungoides due to carbamazepine.

DISCUSSION: Mycosis fungoides is the cutaneous T-cell lymphoma of the skin that needs aggressive chemotherapy and radiation treatment. Pseudo mycosis fungoides is a condition caused by certain drugs that has a similar clinical and histopathologic appearance to mycosis fungoides. When the causative drug is discontinued, the lesions resolve completely.

CONCLUSIONS: An objective causality assessment revealed that carbamazepine was highly probable as the cause of the adverse reaction. Patients who are diagnosed with mycosis fungoides should be asked about any drug use, and clinicians should recognize signs of pseudo mycosis fungoides.

Key Words: carbamazepine, mycosis fungoides, pseudo mycosis fungoides

Published Online, August 8, 2003. www.theannals.com, DOI 10.1345/aph.1D058




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Copyright © 2003 by Harvey Whitney Books Company.