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The Annals of Pharmacotherapy: Vol. 37, No. 11, pp. 1628-1631. DOI 10.1345/aph.1D147
© 2003 Harvey Whitney Books Company.
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Aripiprazole in an Adult with Asperger Disorder

Jud A Staller, MD

Assistant Professor, Department of Psychiatry, State University of New York Upstate Medical University, 750 E. Adams St., Syracuse, NY 13210-2306, FAX 315/464-3202, stallerj{at}upstate.edu

Reprints: Jud A Staller MD

OBJECTIVE: To report a case of aripiprazole-responsive adult Asperger disorder.

CASE SUMMARY: A 34-year-old white man with lifelong, disabling Asperger disorder and a 20-year history of failed psychotherapeutic and pharmacologic interventions was prescribed aripiprazole, with dramatic symptomatic improvement.

DISCUSSION: Multiple prior pharmacologic efforts over several years aimed predominantly at altering serotonin and dopamine neurotransmission resulted in treatment failure due to intolerable adverse effects, exacerbation of underlying symptoms, or nonresponse. Aripiprazole, with a complex profile of neurotransmitter affinities, has produced significant core symptom changes. Improved sociability; increased self-awareness; reduced rigidity, anxiety, and irritability; and reduced preoccupation with circumscribed esoteric interests are among the effects noted.

CONCLUSIONS: Previously intractable Asperger disorder symptoms in a 34-year-old man were ameliorated with aripiprazole.

Key Words: aripiprazole, Asperger disorder

Published Online, September 5, 2003. www.theannals.com, DOI 10.1345/aph.1D147


This article has been cited by other articles:


Home page
 J PsychopharmacolHome page
M. Shastri, L. Alla, and M. Sabaratnam
Aripiprazole use in individuals with intellectual disability and psychotic or behavioural disorders: a case series
J Psychopharmacol, November 1, 2006; 20(6): 863 - 867.
[Abstract] [PDF]


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Copyright © 2003 by Harvey Whitney Books Company.