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The Annals of Pharmacotherapy: Vol. 37, No. 11, pp. 1703-1707. DOI 10.1345/aph.1C483
© 2003 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Venlafaxine Hydrochloride for the Treatment of Hot Flashes

Christina E Schober, PharmD

Pharmacy Practice Resident, University of Pittsburgh Medical Center Health System; Adjunct Instructor, Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, University of Pittsburgh Medical Center

Nicole T Ansani, PharmD

Assistant Professor, Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh; Associate Director, Drug Information Center, University of Pittsburgh Medical Center Health System

Reprints: Christina E Schober PharmD, Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, University of Pittsburgh Medical Center, 200 Lothrop St., 302 Scaife Hall, Pittsburgh, PA 15213-2546, FAX 412/647-5847, schoberce{at}msx.upmc.edu

OBJECTIVE: To review the literature evaluating venlafaxine for the treatment of hot flashes.

DATA SOURCES: Clinical literature accessed through MEDLINE (1966–August 2002), PubMed, Harrison's Online, and references of reviewed articles. Key terms used were venlafaxine, Effexor, hot flashes, and vasomotor symptoms.

DATA SYNTHESIS: Not all patients experiencing hot flashes are candidates for traditional hormonal therapy. Nonhormonal alternatives have long been explored, but conflicting evidence of efficacy exists.

CONCLUSIONS: Venlafaxine is an effective nonhormonal alternative for relief from uncontrolled hot flashes.

Key Words: Effexor, hot flashes, vasomotor symptoms, venlafaxine

Published Online, September 10, 2003. www.theannals.com, DOI 10.1345/aph.1C483


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