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The Annals of Pharmacotherapy: Vol. 37, No. 2, pp. 274-278. DOI 10.1345/aph.1C314
© 2003 Harvey Whitney Books Company.
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Association of HMG-CoA Reductase Inhibitors with Neuropathy

James M Backes, PharmD

Clinical Assistant Professor, Department of Pharmacy Practice and Lipid, Atherosclerosis, Metabolic and LDL-Apheresis Clinic, University of Kansas Medical Center, Kansas City, KS

Patricia A Howard, PharmD FCCP BCPS (AQ Cardiology)

Professor and Vice Chair, Department of Pharmacy Practice, School of Pharmacy, University of Kansas, Kansas City

Reprints: James M Backes PharmD, Department of Pharmacy Practice, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7231, FAX 913/588-2355, E-mail jbackes{at}kumc.edu

OBJECTIVE: To review the possible association between statins and peripheral neuropathy.

DATA SOURCES: Literature was obtained from MEDLINE (1984–September 2002) and International Pharmaceutical Abstracts (1970–June 2002). Key search terms included statin, neuropathy, and HMG-CoA reductase inhibitor.

DATA SYNTHESIS: Epidemiologic studies and case reports suggest an increased risk of peripheral neuropathy with statin drugs. Most patients were receiving long-term therapy, although the onset was highly variable. The majority of cases were at least partially reversible with drug cessation. Specific risk factors or mechanisms have not been identified.

CONCLUSIONS: Observational data suggest a link between chronic statin use and increased risk of peripheral neuropathy. However, the risk appears to be small relative to the significant cardioprotective benefits.

Key Words: HMG-CoA reductase inhibitors, neuropathy, statins

Published Online, January 3, 2003. www.theannals.com, DOI


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