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The Annals of Pharmacotherapy: Vol. 37, No. 3, pp. 392-394. DOI 10.1345/aph.1C237
© 2003 Harvey Whitney Books Company.
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Aztreonam Treatment of Pasteurella multocida Cellulitis and Bacteremia

Jamie S Winner, PharmD

at time of writing, Infectious Diseases Pharmacy Practice Resident, Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK; now, Clinical Specialist, Infectious Diseases, St. Joseph Regional Medical Center, Milwaukee, WI

Chris A Gentry, PharmD

Clinical Specialist, Infectious Diseases, Oklahoma City Veterans Affairs Medical Center

Linda J Machado, MD

Assistant Professor of Medicine, Infectious Diseases Section, The University of Oklahoma Health Sciences Center, Oklahoma City

Paul Cornea, MD

Fellow, Infectious Diseases, The University of Oklahoma Health Sciences Center

Reprints: Chris A Gentry PharmD, Infectious Diseases, Pharmacy Services (119), Oklahoma City Veterans Affairs Medical Center, 921 Northeast 13th St., Oklahoma City, OK 73104-5028, FAX 405/297-5934, E-mail chris.gentry{at}med.va.gov

OBJECTIVE: To report a case of Pasteurella multocida cellulitis and bacteremia treated successfully with aztreonam.

CASE SUMMARY: An 81-year-old white man with multiple antibiotic allergies was admitted with severe cellulitis of the left arm and bacteremia due to P. multocida. The patient was treated for 14 days with aztreonam and had complete resolution of the infection.

DISCUSSION: To our knowledge, this is the first published case describing successful treatment of P. multocida cellulitis and bacteremia with aztreonam. Antimicrobials recommended for use in P. multocida infections include penicillin, ampicillin, amoxicillin, second- and third-generation cephalosporins, tetracyclines, fluoroquinolones, and trimethoprim/sulfamethoxazole. There is very little information in the current literature regarding the activity of aztreonam toward P. multocida.

CONCLUSIONS: This case demonstrates the potential use of aztreonam for P. multocida cellulitis and bacteremia in those instances where antibiotics of choice cannot be given.

Key Words: aztreonam, Pasteurella multocida

Published Online, January 27, 2003. www.theannals.com, DOI 10.1345/aph.1C237


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