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The Annals of Pharmacotherapy: Vol. 37, No. 3, pp. 442-446. DOI 10.1345/aph.1C277
© 2003 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Effect of Cyclooxygenase-2 Inhibitors on Blood Pressure

Deanna L Johnson, PharmD

at time of writing, Specialized Resident, Primary Care, University of Iowa Hospitals and Clinics, Iowa City, IA; now, Clinical Pharmacy Specialist and Assistant Professor (Clinical), Ambulatory Care, Department of Pharmaceutical Care, University of Iowa College of Pharmacy, University of Iowa Hospitals and Clinics

Tina M Hisel, PharmD BCPS

Clinical Pharmacy Specialist and Assistant Professor (Clinical), Ambulatory Care, Department of Pharmaceutical Care, University of Iowa College of Pharmacy, University of Iowa Hospitals and Clinics

Beth Bryles Phillips, PharmD BCPS

Clinical Pharmacy Specialist and Assistant Professor (Clinical), Ambulatory Care, Department of Pharmaceutical Care, University of Iowa College of Pharmacy, University of Iowa Hospitals and Clinics

Reprints: Beth Bryles Phillips PharmD BCPS, Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics, 200 Hawkins Dr., Iowa City, IA 52242-1009, FAX 319/353-8443, E-mail beth-phillips{at}uiowa.edu

OBJECTIVE: To evaluate the effect of cyclooxygenase-2 selective inhibitors (CSIs) on blood pressure.

DATA SOURCES: Clinical literature accessed through MEDLINE (1966–May 2002). Key search terms included COX-2 selective inhibitors; anti-inflammatory agents, nonsteroidal; celecoxib; rofecoxib; and hypertension.

DATA SYNTHESIS: Data from prospective studies on the effects of CSIs on blood pressure are conflicting. Several studies have reported increased blood pressure as an adverse effect of CSIs.

CONCLUSIONS: Additional studies are needed to evaluate the effects of CSIs on blood pressure. CSIs should be used with caution in hypertensive patients and blood pressure monitored closely if a CSI is indicated.

Key Words: blood pressure, celecoxib, cyclooxygenase inhibitors, hypertension, rofecoxib

Published Online, February 3, 2003. www.theannals.com, DOI 10.1345/aph.1C277


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