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The Annals of Pharmacotherapy: Vol. 37, No. 4, pp. 556-563. DOI 10.1345/aph.1C291
© 2003 Harvey Whitney Books Company.
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PSYCHIATRY

Clinical Trial Response and Dropout Rates with Olanzapine Versus Risperidone

Benedetta Santarlasci, PharmD

Researcher, Pharmacoeconomic Laboratory, Italian Society of Hospital Pharmacists, Careggi Hospital, Florence, Italy

Andrea Messori, PharmD

Head, Pharmacoeconomic Laboratory, Italian Society of Hospital Pharmacists, Careggi Hospital

Reprints: Andrea Messori PharmD, Pharmacoeconomic Laboratory, Italian Society of Hospital Pharmacists, Careggi Hospital, viale Morgagni 85, 50134 Firenze, Italy, FAX 39 055 4279738, E-mail md3439{at}mclink.it

BACKGROUND: In schizophrenia, comparing treatment dropouts between olanzapine and risperidone can be useful to better understand their relative effectiveness.

OBJECTIVE: To analyze the differences in the rates of dropout from clinical trials and response between these 2 antipsychotics.

METHODS: Literature search was based on MEDLINE (1966–May 2002). Analysis 1 included 4 randomized studies (838 patients), analysis 2 included 2 randomized studies (n = 716), and analysis 3 assessed 5 clinical studies for olanzapine (n = 928) and 3 for risperidone (n = 290). Odds ratios were estimated by the fixed-effect model.

RESULTS: The risk of treatment discontinuation (analysis 1) was significantly greater for risperidone than for olanzapine (42% vs. 33%, respectively). The response rates were identical for the 2 drugs (analysis 2). A slightly better pattern of maintenance of response was found for olanzapine (analysis 3).

CONCLUSIONS: The pattern of dropout and maintenance of remission seems to be better controlled for olanzapine than for risperidone.

Key Words: clinical trial, dropout, olanzapine, risperidone, schizophrenia

Published Online, February 28, 2003. www.theannals.com, DOI 10.1345/aph.1C291




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