The Annals Summaries of the Latest Medical Research!
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     

The Annals of Pharmacotherapy: Vol. 37, No. 5, pp. 621-624. DOI 10.1345/aph.1C347
© 2003 Harvey Whitney Books Company.
This Article
Right arrow Résumé Freely available
Right arrow Extracto Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spina, S. P
Right arrow Articles by Dillon, E. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Spina, S. P
Right arrow Articles by Dillon, E. C, Jr

PHARMACOKINETICS

Effect of Chronic Probenecid Therapy on Cefazolin Serum Concentrations

Sean P Spina, BScPharm

Clinical Pharmacist — General Medicine, Pharmacy Department, Royal Columbian Hospital, New Westminster, British Columbia, Canada

Edward C Dillon, Jr, BScBA BScPharm PharmD

Clinical Pharmacy Specialist — Emergency Medicine, Pharmacy Department, Royal Columbian Hospital

Reprints: Sean P Spina BScPharm, Pharmacy Department, Royal Columbian Hospital, 330 E. Columbia St., New Westminster, British Columbia V3L 3W7, Canada, FAX 604/520-4802, E-mail sean.spina{at}fraserhealth.ca

OBJECTIVE: To prospectively assess the effectiveness of probenecid at maintaining therapeutic serum concentrations of cefazolin at steady-state by comparing cefazolin serum concentrations produced by intravenous cefazolin 2000 mg every 8 hours with concentrations produced by once-daily administration of intravenous cefazolin 2000 mg plus oral probenecid 500 mg 4 times daily.

METHODS: Patients in this prospective, nonrandomized, unblinded study were identified after an order was written for intravenous cefazolin 2000 mg every 8 hours or once daily plus oral probenecid 500 mg 4 times daily in the emergency department. For both study arms, a peak cefazolin serum concentration was obtained 1 hour after the infusion was started and 23 hours later, prior to the next scheduled dose. Doses of cefazolin for days 2-4 were then administered as ordered. On day 5, peak and trough serum concentrations were drawn 1 hour after the infusion started and 23 hours later, respectively.

RESULTS: A total of 26 patients were prospectively assessed from April 2000 to October 2001. In patients who received cefazolin once daily, the average serum peak and trough concentrations on day 1 were 146.53 and 2.02 mg/L, respectively. Peak and trough concentrations on day 5 were 148.30 and 2.67 mg/L, respectively. In patients who received cefazolin every 8 hours, peak and trough concentrations were 122.15 and 18.65 mg/L on day 1 and, on day 5, 136.51 and 16.98 mg/L, respectively.

CONCLUSIONS: Probenecid 500 mg given orally 4 times daily was effective in maintaining therapeutic serum concentrations of cefazolin at steady-state when given with intravenous cefazolin 2000 mg once daily.

Key Words: cefazolin, once daily, probenecid

Published Online, March 26, 2003. www.theannals.com, DOI 10.1345/aph.1C347


This article has been cited by other articles:


Home page
 The Annals of PharmacotherapyHome page
V. C Cox and P. J Zed
Once-Daily Cefazolin and Probenecid for Skin and Soft Tissue Infections
Ann. Pharmacother., March 1, 2004; 38(3): 458 - 463.
[Abstract] [Full Text] [PDF]


homecopy help contact us subscription past issues search current issue
Copyright © 2003 by Harvey Whitney Books Company.