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Assistant Professor of Pharmacy and Medicine, Department of Pharmacy, Virginia Commonwealth University — MCV Campus, Richmond, VA
Professor of Pharmacy, Department of Pharmacy Practice, Medical University of South Carolina, Charleston, SC
Assistant Professor of Pharmacy, Department of Pharmacy, Virginia Commonwealth University — MCV Campus
Reprints: Michael A Crouch PharmD BCPS, Department of Pharmacy, Virginia Commonwealth University — MCV Campus, 410 N. 12th St., PO Box 980533, Richmond, VA 23298-0533, FAX 804/828-8359, E-mail macrouch{at}vcu.edu
OBJECTIVE: To review the contemporary role of the glycoprotein (GYP) IIb/IIIa receptor inhibitors abciximab, eptifibatide, and tirofiban in patients undergoing percutaneous coronary intervention (PCI) and those with an acute coronary syndrome (ACS), and to provide an algorithm based on currently available evidence for specific agents.
DATA SOURCES: Primary articles were identified by a MEDLINE search (1966–January 2003); references cited in these articles provided additional resources.
STUDY SELECTION AND DATA EXTRACTION: All of the articles identified from data sources were considered for relevant information; this article primarily addresses large, controlled or comparative studies, and meta-analyses.
DATA SYNTHESIS: The role of GYP IIb/IIIa inhibitors in patients undergoing PCI and those with ACS has progressed markedly. To date, abciximab has the most robust data in patients undergoing PCI, particularly high-risk individuals. In PCI patients with lower risk (e.g., elective stenting), eptifibatide is a reasonable first-line option. Data do not support tirofiban for routine use in patients undergoing PCI. For individuals with signs and symptoms of ACS, specifically unstable angina or non–ST-segment elevation myocardial infarction (MI), eptifibatide or tirofiban is recommended in high-risk patients when a conservative approach is used (PCI is not planned). Abciximab is not recommended in this situation. In patients with ST-segment elevation MI (STEMI), abciximab is the only GYP IIb/IIIa inhibitor evaluated in large, well-designed investigations. For medical management in combination with a fibrinolytic agent, the role of abciximab remains unclear. For patients undergoing primary PCI for the management of STEMI, the available evidence supports the use of abciximab, albeit further investigation is warranted.
CONCLUSIONS: The role of GYP IIb/IIIa inhibitors in clinical cardiology continues to evolve. Choice of the agent depends on situation of use, patient-specific characteristics and risk stratification, and, in the case of ACS, chosen management strategy (medical management or intervention).
Key Words: abciximab, acute coronary syndrome, eptifibatide, glycoprotein IIb/IIIa receptor inhibitors, percutaneous coronary intervention, tirofiban
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