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The Annals of Pharmacotherapy: Vol. 38, No. 1, pp. 142-145. DOI 10.1345/aph.1D113
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Use of ß-Blockers in Patients with COPD

Miranda R Andrus, PharmD BCPS

Assistant Clinical Professor of Pharmacy Practice, Harrison School of Pharmacy, Auburn University; Clinical Assistant Professor of Community and Rural Medicine, School of Medicine, University of Alabama, Tuscaloosa, AL

Katherine P Holloway, PharmD

Pharmacy Practice Resident, Department of Pharmacy and Drug Information, Grady Health System, Atlanta, GA

Deidre B Clark, PharmD

Primary Care Resident, Department of Pharmacy, DCH Regional Medical Center, Tuscaloosa, AL

Reprints: Miranda R Andrus PharmD BCPS, 259 Nott Hall, Box 870326, University of Alabama, Tuscaloosa, AL 35487-0001, FAX 205/348-9417, mandrus{at}cchs.ua.edu

OBJECTIVE: To evaluate the safety and cardiovascular benefits of ß-blocker therapy in patients with chronic obstructive pulmonary disease (COPD).

DATA SOURCES: Clinical literature was accessed through MEDLINE (1966–February 2003). Key search terms included chronic obstructive pulmonary disease and adrenergic ß-antagonists.

DATA SYNTHESIS: ß-Blockers are often avoided in patients with COPD because of fear of bronchoconstriction, despite the known cardiovascular mortality benefits. A review of studies evaluating the use of ß-blockers in COPD was undertaken.

CONCLUSIONS: The literature supports the safety and mortality benefits of using ß-blockers in COPD. Patients with mild to moderate COPD should receive cardioselective ß-blocker therapy when a strong indication exists.

Key Words: adrenergic ß-antagonists, chronic obstructive pulmonary disease

Published Online, December 5, 2003. www.theannals.com, DOI 10.1345/aph.1D113


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