The Annals New | Pharmaco Epidemiology and Therapeutic Risk Management
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     

The Annals of Pharmacotherapy: Vol. 38, No. 1, pp. 146-150. DOI 10.1345/aph.1C391
© 2004 Harvey Whitney Books Company.
This Article
Right arrow Résumé Freely available
Right arrow Extracto Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldman, R. D
Right arrow Articles by Scolnik, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldman, R. D
Right arrow Articles by Scolnik, D.

DRUG INFORMATION ROUNDS

Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children

Ran D Goldman, MD

Director, Pediatric Research in Emergency Therapeutics (PRETx) Program Division of Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

Karen Ko, BSc

Researcher, Division of Pediatric Emergency Medicine, The Hospital for Sick Children

Lauren J Linett, BSc

Researcher, Division of Pediatric Emergency Medicine, The Hospital for Sick Children

Dennis Scolnik, MBChB

Staff Physician, Division of Pediatric Emergency Medicine, The Hospital for Sick Children

Reprints: Ran D Goldman MD, Division of Pediatric Emergency Medicine, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada, fax 416/813-5043, ran.goldman{at}sickkids.ca

OBJECTIVE: To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children.

DATA SOURCES: Searches of MEDLINE (1966–November 2003) and EMBASE (1988–November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed.

DATA SYNTHESIS: Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other.

CONCLUSIONS: The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.

Key Words: acetaminophen, children, ibuprofen

Published Online, December 5, 2003. www.theannals.com, DOI 10.1345/aph.1C391


This article has been cited by other articles:


Home page
 DTBHome page
When the child has a fever
DTB, March 1, 2008; 46(3): 17 - 21.
[Abstract] [Full Text] [PDF]


homecopy help contact us subscription past issues search current issue
Copyright © 2004 by Harvey Whitney Books Company.