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The Annals of Pharmacotherapy: Vol. 38, No. 1, pp. 146-150. DOI 10.1345/aph.1C391
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Antipyretic Efficacy and Safety of Ibuprofen and Acetaminophen in Children

Ran D Goldman, MD

Director, Pediatric Research in Emergency Therapeutics (PRETx) Program Division of Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

Karen Ko, BSc

Researcher, Division of Pediatric Emergency Medicine, The Hospital for Sick Children

Lauren J Linett, BSc

Researcher, Division of Pediatric Emergency Medicine, The Hospital for Sick Children

Dennis Scolnik, MBChB

Staff Physician, Division of Pediatric Emergency Medicine, The Hospital for Sick Children

Reprints: Ran D Goldman MD, Division of Pediatric Emergency Medicine, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada, fax 416/813-5043, ran.goldman{at}sickkids.ca

OBJECTIVE: To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children.

DATA SOURCES: Searches of MEDLINE (1966–November 2003) and EMBASE (1988–November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed.

DATA SYNTHESIS: Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other.

CONCLUSIONS: The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.

Key Words: acetaminophen, children, ibuprofen

Published Online, December 5, 2003. www.theannals.com, DOI 10.1345/aph.1C391


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