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Assistant Clinical Professor of Pharmacy Practice, Harrison School of Pharmacy, Auburn University, Huntsville, AL
PharmD Student, Harrison School of Pharmacy, Auburn University
Reprints: Lea S Eiland PharmD, UAB/Division of Pediatrics, 301 Governors Dr., Huntsville, AL 35801-5123, fax 256/551-4453, eilanls{at}auburn.edu
OBJECTIVE: To review the literature of the first nonstimulant approved for treatment of attention-deficit/hyperactivity disorder (ADHD).
DATA SOURCES: Primary literature and review articles were obtained through PubMed/MEDLINE (1966February 2003).
STUDY SELECTION AND DATA EXTRACTION: Literature evaluating atomoxetine in ADHD was selected. Animal data were excluded.
DATA SYNTHESIS: Stimulants are currently first-line therapy for ADHD. However, their use raises several concerns including the potential for abuse and adverse effects. Atomoxetine introduces a new therapeutic drug class, selective norepinephrine-reuptake inhibitors, for ADHD management. This additional treatment option offers potential advantages over current therapies.
CONCLUSIONS: Clinical trials demonstrate that atomoxetine is a safe and effective alternative for ADHD treatment in children and adults; however, its disadvantages may hinder it from becoming a first-line agent.
Key Words: atomoxetine, attention-deficit/hyperactivity disorder
Published Online, December 5, 2003. www.theannals.com, DOI 10.1345/aph.1D144
THIS ARTICLE IS APPROVED FOR CONTINUING EDUCATION CREDIT
ACPE UNIVERSAL PROGRAM NUMBER: 407-000-04-002-H01
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