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The Annals of Pharmacotherapy: Vol. 38, No. 1, pp. 86-90. DOI 10.1345/aph.1D144
© 2004 Harvey Whitney Books Company.
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NEW DRUG APPROVALS

Atomoxetine Treatment of Attention-Deficit/Hyperactivity Disorder

Lea S Eiland, PharmD

Assistant Clinical Professor of Pharmacy Practice, Harrison School of Pharmacy, Auburn University, Huntsville, AL

Abby L Guest

PharmD Student, Harrison School of Pharmacy, Auburn University

Reprints: Lea S Eiland PharmD, UAB/Division of Pediatrics, 301 Governors Dr., Huntsville, AL 35801-5123, fax 256/551-4453, eilanls{at}auburn.edu

OBJECTIVE: To review the literature of the first nonstimulant approved for treatment of attention-deficit/hyperactivity disorder (ADHD).

DATA SOURCES: Primary literature and review articles were obtained through PubMed/MEDLINE (1966–February 2003).

STUDY SELECTION AND DATA EXTRACTION: Literature evaluating atomoxetine in ADHD was selected. Animal data were excluded.

DATA SYNTHESIS: Stimulants are currently first-line therapy for ADHD. However, their use raises several concerns including the potential for abuse and adverse effects. Atomoxetine introduces a new therapeutic drug class, selective norepinephrine-reuptake inhibitors, for ADHD management. This additional treatment option offers potential advantages over current therapies.

CONCLUSIONS: Clinical trials demonstrate that atomoxetine is a safe and effective alternative for ADHD treatment in children and adults; however, its disadvantages may hinder it from becoming a first-line agent.

Key Words: atomoxetine, attention-deficit/hyperactivity disorder

Published Online, December 5, 2003. www.theannals.com, DOI 10.1345/aph.1D144

THIS ARTICLE IS APPROVED FOR CONTINUING EDUCATION CREDIT
ACPE UNIVERSAL PROGRAM NUMBER: 407-000-04-002-H01


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