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Published Online, 17 August 2004, www.theannals.com, DOI 10.1345/aph.1E039.
 The Annals of Pharmacotherapy: Vol. 38, No. 10, pp. 1722-1725. DOI 10.1345/aph.1E039
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Respiratory Stimulant Use in Chronic Obstructive Pulmonary Disease

Melissa J Bales, PharmD

at time of writing, PharmD Student, College of Pharmacy, University of Tennessee, Memphis, TN; now, Walmart Pharmacy, 6522 Chapman Highway, Knoxville, TN

Erin M Timpe, PharmD BCPS

Assistant Professor, College of Pharmacy, University of Tennessee, Drug Information Center, Memphis

Reprints: Erin M Timpe PharmD BCPS, Assistant Professor, College of Pharmacy, University of Tennessee, Drug Information Center, 875 Monroe Ave., Ste. 121, Memphis, TN 38163-4901, fax 901/448-5419, etimpe{at}utmem.edu

OBJECTIVE: To evaluate the use of respiratory stimulants in chronic obstructive pulmonary disease (COPD).

DATA SOURCES: MEDLINE (1966–July 2003) and EMBASE (1980–3rd quarter 2003) were searched using the search terms medroxyprogesterone acetate, acetazolamide, chronic obstructive pulmonary disease, and chronic obstructive lung disease.

DATA SYNTHESIS: Trials are reviewed evaluating ventilatory parameters with acetazolamide and/or medroxyprogesterone in patients with COPD. All studies found improvements in ventilatory parameters, but failed to demonstrate improvements in survival or quality of life.

CONCLUSIONS: Significant improvement in arterial blood gas and ventilatory parameters was reported in COPD patients after acetazolamide and medroxyprogesterone treatment; however, with no improvement in survival or quality of life, the place of these drugs in therapy remains unknown.

Key Words: acetazolamide, chronic obstructive pulmonary disease, medroxyprogesterone acetate

Published Online, August 17, 2004. www.theannals.com, DOI 10.1345/aph.1E039




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