The Annals Evolution of Clinical Pharmacy | Now Available
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     


Published Online, 17 August 2004, www.theannals.com, DOI 10.1345/aph.1E039.
 The Annals of Pharmacotherapy: Vol. 38, No. 10, pp. 1722-1725. DOI 10.1345/aph.1E039
© 2004 Harvey Whitney Books Company.
This Article
Right arrow Résumé Freely available
Right arrow Extracto Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bales, M. J
Right arrow Articles by Timpe, E. M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bales, M. J
Right arrow Articles by Timpe, E. M

DRUG INFORMATION ROUNDS

Respiratory Stimulant Use in Chronic Obstructive Pulmonary Disease

Melissa J Bales, PharmD

at time of writing, PharmD Student, College of Pharmacy, University of Tennessee, Memphis, TN; now, Walmart Pharmacy, 6522 Chapman Highway, Knoxville, TN

Erin M Timpe, PharmD BCPS

Assistant Professor, College of Pharmacy, University of Tennessee, Drug Information Center, Memphis

Reprints: Erin M Timpe PharmD BCPS, Assistant Professor, College of Pharmacy, University of Tennessee, Drug Information Center, 875 Monroe Ave., Ste. 121, Memphis, TN 38163-4901, fax 901/448-5419, etimpe{at}utmem.edu

OBJECTIVE: To evaluate the use of respiratory stimulants in chronic obstructive pulmonary disease (COPD).

DATA SOURCES: MEDLINE (1966–July 2003) and EMBASE (1980–3rd quarter 2003) were searched using the search terms medroxyprogesterone acetate, acetazolamide, chronic obstructive pulmonary disease, and chronic obstructive lung disease.

DATA SYNTHESIS: Trials are reviewed evaluating ventilatory parameters with acetazolamide and/or medroxyprogesterone in patients with COPD. All studies found improvements in ventilatory parameters, but failed to demonstrate improvements in survival or quality of life.

CONCLUSIONS: Significant improvement in arterial blood gas and ventilatory parameters was reported in COPD patients after acetazolamide and medroxyprogesterone treatment; however, with no improvement in survival or quality of life, the place of these drugs in therapy remains unknown.

Key Words: acetazolamide, chronic obstructive pulmonary disease, medroxyprogesterone acetate

Published Online, August 17, 2004. www.theannals.com, DOI 10.1345/aph.1E039




homecopy help contact us subscription past issues search current issue
Copyright © 2004 by Harvey Whitney Books Company.