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Published Online, 17 August 2004, www.theannals.com, DOI 10.1345/aph.1E153.
 The Annals of Pharmacotherapy: Vol. 38, No. 11, pp. 1942-1945. DOI 10.1345/aph.1E153
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Sincalide in Patients with Parenteral Nutrition–Associated Gallbladder Disease

William A Prescott, Jr, PharmD

Clinical Instructor, College of Pharmacy, University of Michigan, Ann Arbor, MI; Specialty Resident in Pediatric Pharmacotherapy, University of Michigan Hospitals and Health Centers

Imad F Btaiche, PharmD BCNSP

Clinical Assistant Professor, College of Pharmacy, University of Michigan; Clinical Pharmacist, University of Michigan Hospitals and Health Centers

Reprints: Imad F Btaiche PharmD BCNSP, Department of Pharmacy Services, University of Michigan Hospitals and Health Centers, UH2D301 Box 0008, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0008, fax 734/936-7027, imadb{at}umich.edu

OBJECTIVE: To review the role of sincalide in treating and preventing parenteral nutrition (PN)–associated gallbladder disease.

DATA SOURCES: A MEDLINE (1996–March 2004) search was performed using the key terms cholecystokinin, sincalide, parenteral nutrition, cholelithiasis, cholestasis, and sludge.

DATA SYNTHESIS: Five human studies investigated the safety and efficacy of sincalide in patients with PN-associated gallbladder disease. Sincalide at intravenous doses of 0.04 µg/kg 3 times daily increased bile flow and improved serum bilirubin levels. However, patients with advanced liver disease did not respond to sincalide therapy. Long-term follow-up data on sincalide effects on liver disease progression are not yet available.

CONCLUSIONS: Sincalide improved the signs of cholestasis. However, its long-term effects in preventing and treating PN-associated gallbladder disease remain unknown and its routine use for this indication cannot be recommended at this time.

Key Words: gall bladder disease, parenteral nutrition, sincalide

Published Online, August 17, 2004. www.theannals.com, DOI 10.1345/aph.1E153




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