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PhD Candidate, Faculty of Pharmacy, Chiang Mai University, Chiang Mai Province, Thailand
Dean, Faculty of Pharmaceutical and Health Sciences, Mahasarakham University, Mahasarakham Province, Thailand
Dean, Faculty of Pharmacy, Chiang Mai University
Board of Neuromedicine, Thailand; Director, Mahasarakham Hospital
Reprints: Phayom Sookaneknun PharmD, Faculty of Pharmaceutical and Health Sciences, Mahasarakham University, Mahasarakham Province 44150, Thailand, fax 0066-(0)43-754360, psookane{at}yahoo.com
BACKGROUND: The practice of pharmaceutical care in primary care settings in Thailand is currently not generally accepted.
OBJECTIVE: To evaluate the effect of pharmacist involvement in treatment with hypertensive patients in primary care settings.
METHODS: The treatment objective was to stabilize the blood pressure (BP) of hypertensive patients in accordance with the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure guidelines. Patients were randomly assigned to a pharmacist-involved group (treatment) or a group with no pharmacist involvement (control). Pre- and post-test BPs, tablet counts, lifestyle modifications, and pharmacists' recommendations were recorded. The 6-month study was carried out in Mahasarakham University pharmacy and 2 primary care units. Patients were monitored monthly by reviewing their medications and supported by providing pharmaceutical care and counseling.
RESULTS: From a total of 235 patients, the treatment group (n = 118)
had a significant reduction in both systolic (S) and diastolic (D) BP compared
with the 117 patients of the control group (p = 0.037, 0.027, respectively).
The 158 patients (76 treatment, 82 control) with BPs 
140/90 mm Hg at the
beginning of the study showed significant BP reductions (p = 0.002 SBP, 0.008
DBP). The proportion of 158 patients whose BP became stabilized was higher in
the treatment group (p = 0.017). The treatment group showed significantly
better adherence (p = 0.014) and exercise control (p = 0.012) at the end of
the study. Physicians accepted 42.72% of medication modifications and 5.34% of
the suggestions for additional investigations.
CONCLUSIONS: Hypertensive patients who received pharmacist input achieved a significantly greater benefit in BP reduction, BP control, and improvement in adherence rate and lifestyle modification.
Key Words: blood pressure, hypertension, pharmaceutical care
Published Online, November 2, 2004. www.theannals.com, DOI 10.1345/aph.1D605
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