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Published Online, 19 October 2004, www.theannals.com, DOI 10.1345/aph.1E143.
 The Annals of Pharmacotherapy: Vol. 38, No. 12, pp. 2145-2149. DOI 10.1345/aph.1E143
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Use of Erythropoietin in Heart Failure Management

Krista Caiola, PharmD

at time of writing, Pharmacy Practice Resident, Mount Sinai Hospital, New York, NY; now, Clinical Pharmacist, Mount Sinai Hospital of Queens, New York

Judy WM Cheng, PharmD BCPS FCCP

Associate Professor of Pharmacy Practice, Long Island University, Long Island, NY; Clinical Pharmacy Specialist of Cardiology, Mount Sinai Medical Center

Reprints: Judy WM Cheng PharmD BCPS FCCP, Mount Sinai Medical Center, One Gustave L Levy Pl., Box 1211, New York, NY 10029-6574, fax 212/987-0198, judy.cheng{at}liu.edu

OBJECTIVE: To review the use of erythropoietin for anemia in heart failure (HF).

DATA SOURCES: Peer-reviewed articles in MEDLINE (1966–June 2004) were identified and citations from available articles were reviewed using the search terms anemia, erythropoietin, and heart failure.

DATA SYNTHESIS: Anemia worsens HF prognosis. Clinical studies in patients with New York Heart Association Class III/IV HF who had hemoglobin <12 mg/dL and were refractory to maximal medical management showed that erythropoietin improves symptoms. Larger scale studies with mortality endpoints are required to confirm the benefits.

CONCLUSIONS: In selected patients with severe, chronic HF, erythropoietin may be considered for functional improvement. However, routine use of this treatment strategy is not recommended until more data are available.

Key Words: anemia, erythropoietin, heart failure

Published Online, October 19, 2004. www.theannals.com, DOI 10.1345/aph.1E143




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