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Published Online, 19 October 2004, www.theannals.com, DOI 10.1345/aph.1E185.
 The Annals of Pharmacotherapy: Vol. 38, No. 12, pp. 2150-2153. DOI 10.1345/aph.1E185
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Adjunctive Granulocyte Colony-Stimulating Factor Therapy for Diabetic Foot Infections

Kelly S Reed, PharmD

Pharmacy Practice Resident, Providence St. Vincent Medical Center, Portland, OR

Manjunath P Pai, PharmD BCPS

Assistant Professor, College of Pharmacy, University of New Mexico, Albuquerque, NM

Reprints: Manjunath P Pai PharmD BCPS, College of Pharmacy, University of New Mexico, 2502 Marble NE, Albuquerque, NM 87131-0001, fax 505/272-6749, apai{at}salud.unm.edu

OBJECTIVE: To evaluate the role of granulocyte colony-stimulating factor (G-CSF) as adjunctive therapy for the treatment of diabetic foot infections in non-neutropenic patients.

DATA SOURCES: Clinical literature was accessed through MEDLINE (1965–April 2004). Key search terms included G-CSF, infection, and diabetes. In addition, relevant references from primary and secondary article bibliographies were extracted.

DATA SYNTHESIS: Three clinical trials evaluating G-CSF for diabetic foot infections were identified. These data demonstrated positive effects of G-CSF on improvement of foot infections and risk of amputations.

CONCLUSIONS: Controlled trials are necessary to validate the role of adjunctive G-CSF at reducing amputations in patients with diabetic foot infections.

Key Words: diabetic foot infections, granulocyte colony-stimulating factor

Published Online, October 19, 2004. www.theannals.com, DOI 10.1345/aph.1E185


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[Abstract] [PDF]


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