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INFECTIOUS DISEASES

Smallpox: Clinical Features, Prevention, and Management

Director of Pharmacy Services and Associate Professor of Medicine, Associate Chief, Section of Clinical Pharmacology, SUNY—Upstate Medical University, Syracuse, NY

Robert Panzik, PharmD

Staff Pharmacist, RiteAid, Shamokin, PA

John A Noviasky, PharmD

Clinical Coordinator, St. Elizabeth Medical Center, Utica, NY

Edward P Krenzelok, PharmD FAACT ABAT

Director, Pittsburgh Poison Center; Professor of Medicine and Pharmacy, University of Pittsburgh, Pittsburgh, PA

Donald C Blair, MD

Chief of Infectious Diseases, Professor of Medicine, SUNY—Upstate Medical University

Reprints: Roy Guharoy PharmD FCP FCCP FASHP, Room 119, University Hospital, 750 E. Adams St., Syracuse, NY 13210-2375, fax 315/464-4221, GuharoyR{at}Upstate.edu

OBJECTIVE: To describe a general overview of smallpox, clinical presentation, diagnosis, adverse events, and management of both pre- and postexposure vaccination.

DATA SOURCES: Literature was identified by search of MEDLINE (1966-June 2003) and International Pharmaceutical Abstracts (1966-May 2003) databases using the key terms smallpox, bioterrorism, biological warfare, and smallpox vaccine.

STUDY SELECTION AND DATA EXTRACTION: Articles identified from data sources were evaluated, and relevant information was included in this review.

DATA SYNTHESIS: Smallpox is spread by human-to-human contact with an infected host and therefore can be contagious. The mortality rate for smallpox is approximately 30%. While the disease was completely eradicated by 1980 with successful use of smallpox vaccine, concern has been raised that smallpox may emerge as a tool of bioterrorism. This concern, combined with the reality of current smallpox vaccination programs in the military and selected civilian populations, mandates a clear understanding of vaccination-related adverse events and contraindications by all healthcare professionals. The vaccine may cause moderate to severe adverse events such as eczema vaccinatum, progressive vaccinia, and generalized vaccinia.

CONCLUSIONS: The balance between the risks and benefits of mass vaccination in prevention of an epidemic is not clear. The Centers for Disease Control and Prevention has established a guideline for appropriate use of smallpox vaccine in the civilian population.

Key Words: bioterrorism, immunization, smallpox

Published Online, January 30, 2004. www.theannals.com, DOI 10.1345/aph.1D272

THIS ARTICLE IS APPROVED FOR CONTINUING EDUCATION CREDIT
ACPE UNIVERSAL PROGRAM NUMBER: 407-000-04-010-H01

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