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Published Online, 23 January 2004, www.theannals.com, DOI 10.1345/aph.1D355.
 The Annals of Pharmacotherapy: Vol. 38, No. 3, pp. 490-493. DOI 10.1345/aph.1D355
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Management of Asymptomatic Bacteriuria in Patients with Diabetes Mellitus

Say-Tat Ooi, MD

Internal Medicine Resident, Akron General Medical Center, Akron, OH

Lawrence A Frazee, PharmD

Pharmacotherapy Specialist, Internal Medicine, Akron General Medical Center; Associate Professor of Clinical Pharmacology in Internal Medicine, Northeastern Ohio Universities College of Medicine, Akron

William G Gardner, MD FACP

Chair, Department of Internal Medicine, Akron General Medical Center; Professor of Medicine, Northeastern Ohio Universities College of Medicine

Reprints: Lawrence A Frazee PharmD, Akron General Medical Center, 400 Wabash Ave., Akron, OH 44307-2463, fax 330/996-2395, lfrazee{at}agmc.org

OBJECTIVE: To review the literature regarding the management of asymptomatic bacteriuria (ASB) in patients with diabetes mellitus.

DATA SOURCES: A MEDLINE (1967-June 2003) and bibliographic search of the English-language literature was conducted using the search terms diabetes mellitus, asymptomatic, bacteriuria, and urinary tract infection.

DATA SYNTHESIS: ASB occurs in diabetic women more commonly than in non-diabetics and is associated with an increased risk of symptomatic urinary tract infection (UTI) among patients with type 2 diabetes. Symptomatic UTIs tend to follow a more complicated course in diabetics. Despite these independent observations, antimicrobial therapy has not been shown to reduce symptomatic UTIs, pyelonephritis, or hospitalization for UTI.

CONCLUSIONS: Available evidence does not support antimicrobial treatment of ASB among patients with diabetes mellitus.

Key Words: bacteriuria, diabetes mellitus

Published Online, January 23, 2004. www.theannals.com, DOI 10.1345/aph.1D355


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