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Published Online, 12 January 2004, www.theannals.com, DOI 10.1345/aph.1D209.
 The Annals of Pharmacotherapy: Vol. 38, No. 3, pp. 498-501. DOI 10.1345/aph.1D209
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Acetylcysteine Treatment for Non-Acetaminophen-Induced Acute Liver Failure

Grant E Sklar, PharmD BCPS

Senior Lecturer, Department of Pharmacy, National University of Singapore; Clinical Pharmacist, Department of Pharmacy, National University Hospital, Singapore

Malar Subramaniam, BScPharm

Pharmacist, KK Women's and Children's Hospital, Singapore

Reprints: Grant E Sklar PharmD BCPS, Department of Pharmacy, National University of Singapore, Block S4 18 Science Dr. 4, Singapore 117543, fax 65-6779-1554, phages{at}nus.edu.sg

OBJECTIVE: To evaluate the effectiveness of intravenous acetylcysteine in the treatment of non-acetaminophen-induced acute liver failure (ALF).

DATA SOURCES: A search of MEDLINE (1966-March 2003), International Pharmaceutical Abstracts (1970-2003), and Cochrane Library (2003, issue 3) databases was conducted, using the search terms acetylcysteine, non-acetaminophen-induced hepatic failure, liver failure, intravenous, and treatment.

DATA SYNTHESIS: All of the studies found were small and do not provide conclusive evidence that acetylcysteine benefits this subgroup of patients. Microvascular regional benefits were seen, but clinical outcomes have not been studied.

CONCLUSIONS: Intravenous acetylcysteine should not be used routinely for treatment of non-acetaminophen-induced ALF. Further large-scale studies are needed to evaluate clinical outcomes.

Key Words: acetylcysteine, liver failure

Published Online, January 12, 2004. www.theannals.com, DOI 10.1345/aph.1D209


This article has been cited by other articles:


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T T Knudsen, S Thorsen, S A Jensen, K Dalhoff, L E Schmidt, U Becker, and F Bendtsen
Effect of intravenous N-acetylcysteine infusion on haemostatic parameters in healthy subjects
Gut, April 1, 2005; 54(4): 515 - 521.
[Abstract] [Full Text] [PDF]


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