The Annals Visit the PharmaCE website!
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     


Published Online, 23 March 2004, www.theannals.com, DOI 10.1345/aph.1D219.
 The Annals of Pharmacotherapy: Vol. 38, No. 5, pp. 887-891. DOI 10.1345/aph.1D219
© 2004 Harvey Whitney Books Company.
This Article
Right arrow Résumé Freely available
Right arrow Extracto Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Woods, T. M
Right arrow Articles by Franks, A. S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Woods, T. M
Right arrow Articles by Franks, A. S

DRUG INFORMATION ROUNDS

Weight Gain Mitigation with Topiramate in Mood Disorders

Tonja M Woods, PharmD

Clinical Assistant Professor of Pharmacy Practice, School of Pharmacy, College of Health Sciences, University of Wyoming, Laramie, WY

Samantha F Eichner, PharmD

Assistant Professor, College of Pharmacy, University of Tennessee; Associate Director, Drug Information Center, University of Tennessee Health Science Center, Memphis, TN

Andrea S Franks, PharmD BCPS

Assistant Professor, Colleges of Pharmacy and Medicine, University of Tennessee Health Science Center

Reprints: Tonja M Woods PharmD, School of Pharmacy, Department 3375, University of Wyoming, 1000 E. University Ave., Laramie, WY 82071-3375, fax 307/766-2953, tmwoods{at}uwyo.edu

OBJECTIVE: To review the evidence of weight loss with use of topiramate in patients with mood disorders.

DATA SOURCES: Literature search included MEDLINE (1966–December 2003), International Pharmaceutical Abstracts (1970–December 2003), and EMBASE (1980–December 2003). Search terms included topiramate, weight loss, adverse effect, mood disorders, bipolar disorder.

DATA SYNTHESIS: Weight gain is a common adverse effect of many agents used to treat mood disorders. Topiramate has been evaluated in the management of some mood disorders, and weight loss may be a beneficial side effect in these patients. Case reports, letters to the editor, prospective investigations, and retrospective observational studies were reviewed to identify evidence of weight loss with topiramate use in patients with mood disorders.

CONCLUSIONS: Current evidence suggests an association between topiramate and weight loss. Based on the limited data, controlled studies need to be conducted to define the role of topiramate in patients with mood disorders who would also benefit from weight reduction.

Key Words: bipolar disorder, mood disorder, topiramate, weight loss

Published Online, March 23, 2004. www.theannals.com, DOI 10.1345/aph.1D219


This article has been cited by other articles:


Home page
 ANN INTERN MEDHome page
Z. Li, M. Maglione, W. Tu, W. Mojica, D. Arterburn, L. R. Shugarman, L. Hilton, M. Suttorp, V. Solomon, P. G. Shekelle, et al.
Meta-Analysis: Pharmacologic Treatment of Obesity
Ann Intern Med, April 5, 2005; 142(7): 532 - 546.
[Abstract] [Full Text] [PDF]


homecopy help contact us subscription past issues search current issue
Copyright © 2004 by Harvey Whitney Books Company.