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Published Online, 27 April 2004, www.theannals.com, DOI 10.1345/aph.1D354.
 The Annals of Pharmacotherapy: Vol. 38, No. 6, pp. 986-988. DOI 10.1345/aph.1D354
© 2004 Harvey Whitney Books Company.
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Successful Treatment of Staphylococcus epidermidis Hip Prosthesis Infection with Oral Linezolid

Ingrid Mogenet, PharmD

Intern, Pharmacy Department, Rangueil University Hospital, Toulouse, France

Sabine Raetz-Dillon, PharmD

Clinical Specialist, Pharmacy Department, Rangueil University Hospital

Jean-Marie Canonge, PharmD

Head of Service, Pharmacy Department, Rangueil University Hospital

Maryse Archambaud, MD

Hospital Expert, Microbiology Department, Rangueil University Hospital

Eric Bonnet, MD

Hospital Expert, Infectious Diseases Department, Rangueil University Hospital

Reprints: Ingrid Mogenet PharmD, Appartement 6A, 2 boulevard Winston Churchill, 63000 Clermont-Ferrand, France, fax 334 73 75 17 59, imogenet{at}chu-clermontferrand.fr

OBJECTIVE: To report a case of Staphylococcus epidermidis infection of a hip prosthesis successfully treated with oral linezolid.

CASE SUMMARY: A 46-year-old woman developed methicillin-resistant S. epidermidis (MRSE) infection of her prosthetic hip. She received oral linezolid 600 mg twice daily for one month; after that time, the biological inflammatory markers returned to normal.

DISCUSSION: One of the most serious complications of arthroplasty is joint prosthesis infection. It is mainly caused by gram-positive bacteria, in particular those of the genus staphylococcus. The increasing prevalence of gram-positive cocci that are resistant to antimicrobial agents has complicated the treatment of serious infections.

CONCLUSIONS: Oral linezolid appears to be an effective and well-tolerated treatment option for hip prosthesis infections due to MRSE.

Key Words: hip prosthesis infection, linezolid, multidrug-resistant Staphylococcus epidermidis

Published Online, April 27, 2004. www.theannals.com, DOI 10.1345/aph.1D354




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Copyright © 2004 by Harvey Whitney Books Company.