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Published Online, 18 May 2004, www.theannals.com, DOI 10.1345/aph.1D537.
 The Annals of Pharmacotherapy: Vol. 38, No. 7, pp. 1283-1285. DOI 10.1345/aph.1D537
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Metformin for Prevention of Type 2 Diabetes

Aleda M Hess

PharmD Student, Raabe College of Pharmacy, Ohio Northern University, Ada, OH

Donald L Sullivan, PhD RPh

Associate Professor of Pharmacy Practice, Raabe College of Pharmacy, Ohio Northern University

Reprints: Donald L Sullivan PhD RPh, Raabe College of Pharmacy, Ohio Northern University, 525 S. Main St., Ada, OH 45810-9989, fax 419/772-1917, d-sullivan{at}onu.edu

OBJECTIVE: To evaluate evidence from the medical literature that metformin is effective in preventing type 2 diabetes.

DATA SOURCES: Primary literature was accessed via a MEDLINE search (1966–December 2003) using the terms metformin, type 2 diabetes, and prevention.

DATA SYNTHESIS: Two studies evaluated metformin's potential to prevent type 2 diabetes, finding that metformin maintained or reduced fasting blood glucose in non-diabetics. Recently, a large study by the Diabetes Prevention Program showed that metformin may reduce the incidence of diabetes. Researchers compared lifestyle changes, metformin therapy, and placebo groups. They found that both lifestyle changes (58%) and metformin therapy (31%) significantly reduced the occurrence of type 2 diabetes versus placebo.

CONCLUSIONS: These studies provide evidence that metformin may reduce the occurrence of type 2 diabetes. Because long-term efficacy has not been determined, further studies are needed.

Key Words: metformin, prevention, type 2 diabetes

Published Online, May 18, 2004. www.theannals.com, DOI 10.1345/aph.1D537




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