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Published Online, 1 June 2004, www.theannals.com, DOI 10.1345/aph.1D293.
 The Annals of Pharmacotherapy: Vol. 38, No. 7, pp. 1297-1300. DOI 10.1345/aph.1D293
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Relationship Between MMR Vaccine and Autism

Kristin C Klein, PharmD

Clinical Assistant Professor, Clinical Sciences Department, College of Pharmacy, University of Michigan, Ann Arbor, MI; Clinical Pharmacist, Pharmacy Services, University of Michigan Health System

Emily B Diehl, PharmD

at time of writing, PharmD Student, School of Pharmacy, University of Missouri, Kansas City; now, Pediatric Pharmacotherapy Resident, University of Tennessee Health Science Center and Le Bonheur Children's Medical Center, Memphis, TN

Reprints: Kristin C Klein PharmD, University of Michigan Health System, MCHC F2758, Box 0221, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0221, fax 734/936-6946, kriklein{at}umich.edu

OBJECTIVE: To evaluate the proposed link between the administration of the measles, mumps, and rubella (MMR) vaccine and the development of autism.

DATA SOURCES: A literature search utilizing MEDLINE (1966–November 2003), with the key terms measles, mumps, rubella, and autism, was conducted. Review of the references listed in the articles identified was also performed.

DATA SYNTHESIS: Ten articles that specifically evaluated the possible relationship between the MMR vaccine and autism were identified. Review articles, commentaries, and evaluations of a link between gastrointestinal symptoms in autistic children and MMR immunization were excluded.

CONCLUSIONS: Based upon the current literature, it appears that there is no relationship between MMR vaccination and the development of autism.

Key Words: autism, MMR vaccine

Published Online, June 1, 2004. www.theannals.com, DOI 10.1345/aph.1D293




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