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Published Online, 13 July 2004, www.theannals.com, DOI 10.1345/aph.1D632.
 The Annals of Pharmacotherapy: Vol. 38, No. 9, pp. 1525-1528. DOI 10.1345/aph.1D632
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

False-Positive Urine Opiate Screening Associated with Fluoroquinolone Use

Jennifer L Zacher, PharmD

at time of writing, PharmD Student, University of Illinois at Chicago, Chicago, IL; now, Psychiatric Pharmacy Resident, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH

Donna M Givone, PharmD BCPP

Clinical Pharmacy Specialist in Psychiatry/Clinical Assistant Professor, Jesse Brown Department of Veterans Affairs Medical Center, University of Illinois at Chicago

Reprints: Donna M Givone PharmD BCPP, Pharmacy Service (119), 820 S. Damen Ave., Chicago, IL 60612-4223, fax 312/569-8122, donna.givone{at}med.va.gov

OBJECTIVE: To review the literature regarding false-positive urine opiate screens associated with the use of fluoroquinolones.

DATA SOURCES: Literature was identified using MEDLINE (1966–February 2004), EMBASE, and all EBM Reviews with the terms quinolones, substance abuse detection, opiates, cross-reactions, false-positive reactions, and each fluoroquinolone. Article references were also reviewed.

DATA SYNTHESIS: Various settings utilize the practice of screening for drugs of abuse, such as opiates. These screening procedures can impact aspects of one's life, such as employment; therefore, accuracy is of the utmost importance. Two clinical trials were evaluated which showed that certain fluoroquinolone antibiotics cross-react with some of the commonly used urine opiate screening immunoassays. This suggests the importance of verifying positive results in instances where one's livelihood can be affected.

CONCLUSIONS: Fluoroquinolones can cause false-positive urine opiate screens. Clinicians should be aware of this potential interaction and may need to verify positive results.

Key Words: fluoroquinolones, opiate, urine screening

Published Online, July 13, 2004. www.theannals.com, DOI 10.1345/aph.1D632


This article has been cited by other articles:


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 Annals of Clinical & Laboratory ScienceHome page
G. M. Reisfield, E. Salazar, and R. L. Bertholf
Rational Use and Interpretation of Urine Drug Testing in Chronic Opioid Therapy
Ann. Clin. Lab. Sci., January 1, 2007; 37(4): 301 - 314.
[Abstract] [Full Text] [PDF]


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