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Published Online, 16 November 2004, www.theannals.com, DOI 10.1345/aph.1E392.
 The Annals of Pharmacotherapy: Vol. 39, No. 1, pp. 150-152. DOI 10.1345/aph.1E392
© 2005 Harvey Whitney Books Company.
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Coadministration of Gatifloxacin and Multivitamin Preparation Containing Minerals: Potential Treatment Failure in an Elderly Patient

Louise Mallet, PharmD

Associate Clinical Professor, Faculty of Pharmacy, University of Montréal, Québec, Canada; Clinical Pharmacist in Geriatrics, McGill University Health Centre, Montréal

Allen Huang, MDCM FRCPC

Director, Division of Geriatric Medicine; Geriatrician, McGill University Health Centre; Associate Professor of Medicine, McGill University

Reprints: Dr. Mallet, Faculty of Pharmacy, University of Montréal, C.P. 6128, Succursale Centre-Ville, Montréal H3C 3J7, Québec, Canada, fax 514/343-6120, louise.mallet{at}umontreal.ca

OBJECTIVE: To report a case of probable treatment failure in a patient receiving gatifloxacin and a multivitamin preparation containing minerals.

CASE SUMMARY: A 77-year-old white woman was prescribed gatifloxacin for hospital-acquired bacterial pneumonia. She was also receiving calcium carbonate 500 mg twice daily and a multivitamin preparation containing minerals once a day. Three days after gatifloxacin was started, the patient was still febrile, coughing, and not responding clinically. It was noted that nurses were administering the gatifloxacin tablet at the same time as the multivitamin tablet. The time of administration for gatifloxacin was changed to 6 hours after the patient received her multivitamin preparation. Two days later, she clinically improved.

DISCUSSION: Studies have shown that the bioavailability of gatifloxacin is decreased with concurrent administration of antacids containing aluminum or magnesium; dietary supplements containing zinc, magnesium, and iron; multivitamin preparations containing minerals; and sucralfate. An objective causality assessment revealed that the adverse drug effect was probable.

CONCLUSIONS: This case illustrates the need to recognize this potential interaction and to know how to avoid possible treatment failure.

Key Words: gatifloxacin, multivitamin preparation containing minerals, treatment failure

Published Online, November 16, 2004. www.theannals.com, DOI 10.1345/aph.1E392


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[Abstract] [Full Text] [PDF]


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