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Published Online, 30 November 2004, www.theannals.com, DOI 10.1345/aph.1E037.
 The Annals of Pharmacotherapy: Vol. 39, No. 1, pp. 95-101. DOI 10.1345/aph.1E037
© 2005 Harvey Whitney Books Company.
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OBSTETRICS/GYNECOLOGY

High- versus Low-Dose Oxytocin for Augmentation or Induction of Labor

John H Patka, PharmD

Clinical Pharmacist, Department of Pharmacy and Drug Information, Grady Health System, Atlanta, GA

Amy E Lodolce, PharmD BCPS

Drug Information Specialist; Clinical Assistant Professor, Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL

Angela K Johnston, PharmD

Clinical Coordinator—Drug Information, New York Presbyterian Hospital, New York, NY

Reprints: Dr. Patka, Department of Pharmacy and Drug Information, Grady Health System, 80 Jessie Hill Jr. Dr., SE, Atlanta, GA 30303-3031, fax 404/616-2227, jpatka{at}gmh.edu

OBJECTIVE: To compare the use of high- and low-dose oxytocin for augmentation or induction of labor.

DATA SOURCES: Clinical trials were accessed through MEDLINE (1966-November 2003). Published literature relevant to the use of oxytocin for augmentation or induction of labor was evaluated.

STUDY SELECTION AND DATA EXTRACTION: Articles identified from the data sources were evaluated and included if they were clinical trials comparing high-versus low-dose oxytocin for augmentation or induction of labor.

DATA SYNTHESIS: Oxytocin is a treatment of choice for augmentation and induction of labor; however, no consensus exists regarding optimal dosing. Relevant studies comparing high-dose (2-6 mU/min) and low-dose (1-2 mU/min) therapy for labor augmentation and induction were evaluated.

CONCLUSIONS: High-dose oxytocin decreases the time from admission to vaginal delivery, but does not appear to decrease the incidence of cesarean sections when compared with low-dose therapy.

Key Words: augmentation, induction, labor, oxytocin

Published Online, November 30, 2004. www.theannals.com, DOI 10.1345/aph.1E037

THIS ARTICLE IS APPROVED FOR CONTINUING EDUCATION CREDIT
ACPE UNIVERSAL PROGRAM NUMBER: 407-000-05-004-H01




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