The Annals Evolution of Clinical Pharmacy | Now Available
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     


Published Online, 13 September 2005, www.theannals.com, DOI 10.1345/aph.1G171.
 The Annals of Pharmacotherapy: Vol. 39, No. 10, pp. 1617-1619. DOI 10.1345/aph.1G171
© 2005 Harvey Whitney Books Company.
This Article
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Onat, D.
Right arrow Articles by Colombo, P. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Onat, D.
Right arrow Articles by Colombo, P. C

CARDIOLOGY

Reliability of Nesiritide Infusion via Non-Primed Tubing and Heparin-Coated Catheters

Duygu Onat, PhD1, John Stathopoulos, MD2, Andrew Rose, MD3, Karel Newman, PhD4, Robert R Sciacca, Eng ScD5, Ulrich P Jorde, MD6, and Paolo C Colombo, MD7

1 Postdoctoral Research Fellow, Department of Medicine, Columbia University, New York, NY
2 Cardiology Fellow, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY
3 Student, Columbia University
4 Product Support Development, Biosite Inc., San Diego, CA
5 Research Scientist, Department of Medicine, Columbia University
6 Director, Heart Failure Center; Assistant Professor of Medicine, School of Medicine, New York University, New York
7 Assistant Professor of Medicine, Department of Medicine, Columbia University

Reprints: Dr. Colombo, New York-Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, PH Bldg., Rm. 1291, 622 W. 168th St., New York, NY 10032, fax 212/305-7439, pcc2001{at}columbia.edu

BACKGROUND: Prescribing information for nesiritide mandates priming of intravenous tubing prior to connecting to the patient's intravenous access because the drug may adsorb to the line. As of this writing, no published study has quantified the binding effect of nesiritide to intravenous tubing.

OBJECTIVE: To investigate whether priming of peripheral intravenous tubing is necessary and whether nesiritide can be reliably delivered through central intravenous lines, including heparin-coated catheters, where priming cannot occur.

METHODS: A 23.3-mL bolus of nesiritide followed by a 7-mL/h 2-hour infusion were run through (1) polyvinylchloride (PVC) peripheral intravenous tubing primed with nesiritide, (2) non-primed PVC peripheral intravenous tubing, (3) non-primed polyethylene peripheral intravenous tubing, (4) non-primed PVC peripheral intravenous tubing connected to a central intravenous polyurethane catheter, and (5) non-primed PVC peripheral intravenous tubing connected to a heparin-coated pulmonary artery PVC catheter. Nesiritide concentrations were measured in the intravenous bags and in samples collected from the 5 intravenous settings.

RESULTS: Priming of intravenous tubing with nesiritide did not increase drug recovery: at least 94% of the bolus dose and 96% of the total drug were recovered from all intravenous sets.

CONCLUSIONS: Infusion of nesiritide via non-primed peripheral and central intravenous tubing, including heparin-coated pulmonary catheter, is reliable. Changes in nesiritide labeling appear to be warranted.

Key Words: nesiritide, intravenous line, priming

Published Online, September 13, 2005. www.theannals.com, DOI 10.1345/aph.1G171




homecopy help contact us subscription past issues search current issue
Copyright © 2005 by Harvey Whitney Books Company.