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Published Online, 15 November 2005, www.theannals.com, DOI 10.1345/aph.1G275.
 The Annals of Pharmacotherapy: Vol. 39, No. 12, pp. 2096-2099. DOI 10.1345/aph.1G275
© 2005 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Effect of Bupropion on Sexual Dysfunction

Regina Ginzburg, PharmD1, Yvonne Wong, PharmD2, and Jonathan S Fader, PhD3

1 Assistant Clinical Professor, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, NY
2 Pharmacy Practice Resident, Veterans Affairs New York Harbor Healthcare System, New York Campus, New York, NY
3 Clinical Psychologist, Beth Israel Residency in Urban Family Practice—Institute for Urban Family Health; Assistant Professor of Family Medicine, Albert Einstein College of Medicine of Yeshiva University, New York, NY

Reprints: Dr. Ginzburg, College of Pharmacy and Allied Health Professions, St. John's University, 8000 Utopia Pkwy., St. Albert's Hall, Rm. 114, Jamaica, NY 11439-0001, fax 718/990-1986, ginzburr{at}stjohns.edu

OBJECTIVE: To determine the role of bupropion in treatment of sexual dysfunction.

DATA SOURCES: Studies and case reports were identified through MEDLINE (1970-July 2005) using search terms bupropion, antidepressants, sexual function, and sexual dysfunction.

DATA SYNTHESIS: Bupropion has been shown to have a favorable effect on sexual dysfunction. Several reports and small, short-term trials have examined bupropion as an adjunct or substitute for other antidepressants in sexually dysfunctional patients. Use of bupropion has also been studied in nondepressed patients. Bupropion may be a promising medication for treating sexual dysfunction. However, specific dosing is unclear.

CONCLUSIONS: While the studies reviewed here demonstrated some benefit in using bupropion to treat sexual dysfunction, limitations exist. Future studies should be conducted using larger sample sizes.

Key Words: bupropion, sexual dysfunction

Published Online, November 15, 2005. www.theannals.com, DOI 10.1345/aph.1G275




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Copyright © 2005 by Harvey Whitney Books Company.