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ONCOLOGY

Palonosetron HCl Compatibility and Stability with Doxorubicin HCl and Epirubicin HCl During Simulated Y-Site Administration

Director, Clinical Pharmaceutics Research, The University of Texas, MD Anderson Cancer Center, Houston, TX

Yanping Zhang, BS

Research Investigator, Clinical Pharmaceutics Research, The University of Texas, MD Anderson Cancer Center

Reprints: Mr. Trissel, Division of Pharmacy Unit 90, UTMD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030-4095, fax 713/796-1910,

BACKGROUND: Palonosetron HCl is a selective 5-HT₃ receptor antagonist used for the prevention of chemotherapy-induced nausea and vomiting. Palonosetron HCl may be administered with other drugs by Y-site administration, including doxorubicin HCI and epirubicin HCI. Consequently, stability and compatability information are needed to verify the acceptability of such Y-site administration.

OBJECTIVE: To evaluate the physical and chemical stability of undiluted palonosetron HCl 50 µg/mL with doxorubicin HCl 1 mg/mL and epirubicin HCl 0.5 mg/mL during simulated Y-site administration.

METHODS: Triplicate samples of palonosetron HCl with each of the anthracycline chemotherapy drugs were tested. Samples were stored and evaluated for up to 4 hours at room temperature near 23 °C. Physical stability was assessed using turbidimetric and particulate measurement, as well as visual inspection. Chemical stability was assessed by HPLC.

RESULTS: All of the admixtures were clear and red-orange when viewed in normal fluorescent room light and with a Tyndall beam. Measured turbidity and particulate content were low initially and remained low throughout the study. The drug concentration was unchanged in any of the samples throughout the study.

CONCLUSIONS: Palonosetron HCl is physically and chemically stable with doxorubicin HCl and epirubicin HCl during simulated Y-site administration of these drugs over 4 hours at ambient room temperature.

Key Words: compatibility, doxorubicin, epirubicin, palonosetron, stability

Published Online, December 21, 2004. www.theannals.com, DOI 10.1345/aph.1E408

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