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Anasarca Edema with Amlodipine Treatment

Didem ener, MD

Internal Medicine Resident, Medical Faculty, Department of Internal Medicine, Hacettepe University, Ankara, Turkey

M Halil, MD

Internal Medicine Specialist, Fellow of Geriatrics, Medical Faculty, Department of Internal Medicine, Division of Geriatrics, Hacettepe University

Burcu Balam Yavuz, MD

Internal Medicine Resident, Medical Faculty, Department of Internal Medicine, Hacettepe University

Mustafa Cankurtaran, MD

Internal Medicine Specialist, Fellow of Geriatrics, Medical Faculty, Department of Internal Medicine, Division of Geriatrics, Hacettepe University

Servet Arioul, MD

Professor of Internal Medicine, Medical Faculty, Department of Internal Medicine, Division of Geriatrics, Hacettepe University

Reprints: Dr. Cankurtaran, Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, 06100 Sihhiye, Ankara, Turkey, fax 90-312-72-08, mcankurt{at}hacettepe.edu.ctr

OBJECTIVE: To report a case of anasarca edema associated with amlodipine use.

CASE SUMMARY: A 77-year-old woman with essential hypertension who had not been treated with any other drug was prescribed amlodipine 10 mg/day to control her blood pressure. She developed anasarca edema soon after amlodipine treatment was initiated. Laboratory test results for possible etiologies were negative. Discontinuation of amlodipine resulted in dramatic improvement.

DISCUSSION: To our knowledge, as of February 3, 2005, there have been no other reports of amlodipine-related anasarca edema in the English literature, and only one case was described in the Japanese literature. Pretibial edema is the most common adverse effect of amlodipine. Periocular and perioral edema have occurred less frequently, but anasarca edema has not emerged as a problem. An objective causality assessment revealed amlodipine to be a probable cause of anasarca edema.

CONCLUSIONS: In rare instances, amlodipine may cause generalized edema, which will resolve upon discontinuation of the drug.

Key Words: amlodipine, anasarca edema

Published Online, February 22, 2005. www.theannals.com, DOI 10.1345/aph.1E410

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