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Published Online, 29 August 2006, www.theannals.com, DOI 10.1345/aph.1H208.
 The Annals of Pharmacotherapy: Vol. 40, No. 10, pp. 1884-1886. DOI 10.1345/aph.1H208
© 2006 Harvey Whitney Books Company.
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Paroxetine Useful for Palmar-Plantar Hyperhidrosis

Samir Kumar Praharaj, DPM

Junior Resident, Central Institute of Psychiatry, Ranchi, Jharkhand, India

Manu Arora, MD DPM

Senior Resident, Central Institute of Psychiatry

Reprints: Dr. Praharaj, Central Institute of Psychiatry, Ranchi, Jharkhand, India 834006, samirpsyche{at}yahoo.co.in

OBJECTIVE: To report a case of palmar-plantar hyperhidrosis (PPH) in which paroxetine was found to be helpful.

CASE SUMMARY: A 32-year-old man with a history of excessive sweating of the palms and soles since childhood was diagnosed with PPH and was prescribed paroxetine 10 mg/day, which was increased to 20 mg/day. After one month, he experienced a marked reduction in sweating and improvement in socio-occupational functioning, which were sustained during follow-up at 6 months without any emergent adverse effects.

DISCUSSION: Paroxetine's anticholinergic action may be responsible for its beneficial effect in PPH, as it may override the adrenergic mechanism, which has a minor effect on sweating from eccrine glands. Alternatively, paroxetine's beneficial effect in PPH may be secondary to its antianxiety effect, through central mechanisms.

CONCLUSIONS: Paroxetine may be a useful option in the treatment of PPH.

Key Words: palmar-plantar hyperhidrosis, paroxetine

Published Online, August 29, 2006. www.theannals.com, DOI 10.1345/aph.1H208


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