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Published Online, 28 November 2006, www.theannals.com, DOI 10.1345/aph.1H325.
 The Annals of Pharmacotherapy: Vol. 40, No. 12, pp. 2273-2275. DOI 10.1345/aph.1H325
© 2006 Harvey Whitney Books Company.
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Clozapine Effective in Olanzapine-Induced Pisa Syndrome

Manu Arora, MD DPM

Senior Resident in Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India

Samir Kumar Praharaj, DPM

Junior Resident in Psychiatry, Central Institute of Psychiatry

Sukanto Sarkar, DPM

Junior Resident in Psychiatry, Central Institute of Psychiatry

Reprints: Dr. Arora, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India 834006, drmanu2004{at}rediffmail.com

OBJECTIVE: To report a case of olanzapine-induced Pisa syndrome that improved after treatment with clozapine.

CASE SUMMARY: A 22-year-old male with paranoid schizophrenia presented with insidious onset tonic truncal flexion with axial rotation and difficulty in walking after exposure to olanzapine in doses up to 15 mg/day for 9 months. An objective causality assessment suggested that Pisa syndrome was probably related to olanzapine. There was improvement in his symptoms after 6 weeks of treatment with clozapine in doses gradually titrated to 350 mg/day.

DISCUSSION: Pisa syndrome is a type of dystonia that has been associated with both typical and atypical antipsychotics. Both acute and insidious onset cases have been described in the literature, which have different course and treatment response. Clozapine was found to be effective in reducing the severity of olanzapine-induced Pisa syndrome.

CONCLUSION: Clozapine may be a useful treatment option for Pisa syndrome that has been caused by olanzapine.

Key Words: clozapine, olanzapine, Pisa syndrome

Published Online, November 28, 2006. www.theannals.com, DOI 10.1345/aph.1H325




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Copyright © 2006 by Harvey Whitney Books Company.