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Published Online, 24 January 2006, www.theannals.com, DOI 10.1345/aph.1G276.
 The Annals of Pharmacotherapy: Vol. 40, No. 3, pp. 501-505. DOI 10.1345/aph.1G276
© 2006 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

Role of Buprenorphine in the Management of Heroin Addiction

Soojin Sung, PharmD

Pharmacy Practice Resident, Department of Pharmacy, Bronx Veterans Affairs Medical Center, Bronx, NY

John M Conry, PharmD BCPS

Assistant Clinical Professor, Clinical Coordinator of Pharmaceutical Care Services Project Renewal, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, NY

Reprints: Dr. Conry, College of Pharmacy and Allied Health Professions, St. John's University, St. Albert's Hall, Rm. 114, 8000 Utopia Pkwy., Jamaica, NY 11439-0001, fax 718/990-1986, conryj{at}stjohns.edu

OBJECTIVE: To review buprenorphine and explore its role in the treatment of heroin dependence.

DATA SOURCES: Articles were identified through a search of MEDLINE (1966–February 2005) using the key terms buprenorphine, heroin, opioid, addiction, and methadone.

DATA SYNTHESIS: Buprenorphine appears to provide potential advantages over methadone. Two Cochrane meta-analyses were evaluated on the use of buprenorphine in opioid dependence—one in the management of opioid dependence and the other in the management of opioid withdrawal.

CONCLUSIONS: Buprenorphine offers several advantages for the treatment of heroin addiction. As maintenance treatment, buprenorphine is effective, but not more effective than methadone. In the management of opioid withdrawal, buprenorphine may be better tolerated than clonidine or methadone.

Key Words: addiction, buprenorphine, heroin, opioid

Published Online, January 24, 2006. www.theannals.com, DOI 10.1345/aph.1G276




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