The Annals Holiday Offer - Save 50%
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     


Published Online, 25 April 2006, www.theannals.com, DOI 10.1345/aph.1G555.
 The Annals of Pharmacotherapy: Vol. 40, No. 5, pp. 980-982. DOI 10.1345/aph.1G555
© 2006 Harvey Whitney Books Company.
This Article
Right arrow Résumé Freely available
Right arrow Extracto Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vesta, K. S
Right arrow Articles by Kozlowski, E. A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vesta, K. S
Right arrow Articles by Kozlowski, E. A

Propofol-Induced Priapism, a Case Confirmed with Rechallenge

Kimi S Vesta, PharmD BCPS

Assistant Professor, Department of Pharmacy, Clinical and Administrative Sciences, College of Pharmacy, University of Oklahoma, Oklahoma City, OK

Shaunta' D Martina, PharmD

Internal Medicine Pharmacy Practice Resident, Department of Pharmacy, Clinical and Administrative Sciences, College of Pharmacy, University of Oklahoma

Ellen A Kozlowski, DPh

Pharmacy Clinical Coordinator, Department of Pharmacy, OU Medical Center, Oklahoma City

Reprints: Dr. Vesta, College of Pharmacy, PO Box 26901, Oklahoma City, OK 73190-5040, fax 405/271-6430, Kimi-Vesta{at}ouhsc.edu

OBJECTIVE: To report a case of propofol-induced priapism.

CASE SUMMARY: A 17-year-old male receiving propofol for induction of anesthesia during a cardiac ablation procedure developed priapism that required medical intervention and discontinuation of propofol. The priapism developed after a total propofol dose of 550 mg, lasted for 2 hours, and resolved immediately following medical intervention. The following day, the patient underwent a transesophageal echocardiogram and received a total propofol dose of 40 mg throughout the procedure. He again developed priapism, which resolved within one hour without medical intervention.

DISCUSSION: Priapism experienced by this patient is considered to be drug-induced because of the temporal relationship, recurrence with rechallenge, and dose-response relationship. Using the Naranjo probability scale, we determined that propofol was a highly probable causative agent of priapism in this patient.

CONCLUSIONS: Although, as of April 4, 2006, this adverse effect has not been previously reported, there is a strong correlation of propofol to priapism in this patient. Clinicians should be aware of this adverse effect.

Key Words: priapism, propofol

Published Online, April 25, 2006. www.theannals.com, DOI 10.1345/aph.1G555




homecopy help contact us subscription past issues search current issue
Copyright © 2006 by Harvey Whitney Books Company.