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CARDIOLOGY

Hospital Policies for Treatment of Acute Decompensated Heart Failure

Research Fellow, Center for Pharmacoeconomic Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL

Robert J DiDomenico, PharmD

Clinical Associate Professor, Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago

Jeffrey E Wojtynek, PharmD

Director, Clinical/Contracting Pharmacy Integration, Consorta, Inc., Schaumburg, IL

John C Theobald, PharmD

Director, Clinical Pharmacy Services, Consorta, Inc., Schaumburg

Glen T Schumock, PharmD MBA FCCP

Director and Associate Professor, Center for Pharmacoeconomic Research, College of Pharmacy, University of Illinois at Chicago

Reprints: Dr. Schumock, Department of Pharmacy Practice, 833 S. Wood St. (M/C 886), Chicago, IL 60612, fax 312/996-0424, schumock{at}uic.edu

BACKGROUND: It is unclear to what extent hospitals use guidelines or protocols in treating acute decompensated heart failure (ADHF) and whether nesiritide is included in these guidelines or protocols.

OBJECTIVE: To assess the formulary status of currently used drugs, therapeutic guidelines, and perceptions about the appropriateness of treatment of ADHF in community hospitals.

METHODS: A Web-based survey of pharmacy directors at community hospitals that were part of a national group purchasing organization was conducted.

RESULTS: One hundred seven hospitals participated in the survey (response rate 47.1%). Diuretics such as furosemide and bumetanide were more commonly included (100% and 94.4%, respectively) on hospital formularies than was torsemide (69.2%). Dopamine and dobutamine were more common (94.4% each) on the formulary than was milrinone (68.2%). Nitroprusside and nitroglycerin were listed on the formularies of more than 90% of participating institutions, while nesiritide was listed on the formularies in only 48.6% of hospitals and was placed on restricted status in 36.4% of hospitals. Guidelines for care of patients with ADHF were used in the emergency department (ED), inpatient care units, and outpatient clinics in 18.6%, 43.0%, and 8.5% of hospitals, respectively. Overall, ADHF care, including general treatment as well as specific use of nesiritide, was deemed appropriate in the majority of patients, but nearly twice as many respondents perceived the management of ADHF and specific use of nesiritide as inappropriate in the ED compared with inpatient treatment. Only 41.1% of the respondents reported following Braunwald recommendations for the use of nesiritide.

CONCLUSIONS: A sizable percentage of responding community hospitals do not have guidelines for treatment of ADHF despite the existence of such guidelines in the literature. There are opportunities for improvement in the general treatment of ADHF as well as for the use of nesiritide in ADHF, especially in the ED or observation unit versus inpatient units.

Key Words: acute decompensated heart failure, diuretics, guidelines, nesiritide

Published Online, March 20, 2007. www.theannals.com, DOI 10.1345/aph.1H664