The Annals Evolution of Clinical Pharmacy | Now Available
home help contact us subscription past issues search current issue
 QUICK SEARCH:   [advanced]


     



Published Online, 22 July 2008, www.theannals.com, DOI 10.1345/aph.1L181.
The Annals of Pharmacotherapy: Vol. 42, No. 9, pp. 1208-1215. DOI 10.1345/aph.1L181
© 2008 Harvey Whitney Books Company.
This Article
Right arrow Résumé Freely available
Right arrow Extracto Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mann, D.
Right arrow Articles by Muntner, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mann, D.
Right arrow Articles by Muntner, P.

DYSLIPIDEMIA

Trends in Statin Use and Low-Density Lipoprotein Cholesterol Levels Among US Adults: Impact of the 2001 National Cholesterol Education Program Guidelines

Devin Mann, MD MS

Assistant Professor of Medicine, Mount Sinai School of Medicine, New York, NY

Kristi Reynolds, PhD MPH

Research Scientist/Epidemiologist, Kaiser Permanente Southern California, Pasadena, CA

Donald Smith, MD

Associate Professor of Medicine, Mount Sinai School of Medicine

Paul Muntner, PhD

Associate Professor of Community and Preventive Medicine, Mount Sinai School of Medicine

Reprints: Dr. Mann, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1087, New York, NY, 10029, fax 212/831-8116, devin.mann{at}mssm.edu

BACKGROUND: Few data are available on the use of statins after publication of the National Cholesterol Education Program Third Adult Treatment Panel (ATP-III) guidelines in 2001.

OBJECTIVE: To determine changes in statin use and its impact on low-density lipoprotein cholesterol (LDL-C) control among US adults from 1999 to 2004.

METHODS: High LDL-C levels and statin use among 1911 participants of the National Health and Nutrition Examination Survey (NHANES) 2003–2004 were determined and compared with 1770 and 2094 participants of NHANES 1999–2000 and NHANES 2001–2002, respectively. Statin use was obtained from review of participants' drug containers. High LDL-C levels and LDL-C control were defined, using risk-specific cut-points from the ATP-III guidelines.

RESULTS: Statins were taken by 24 million Americans in 2003–2004, an increase from 12.5 million in 1999–2000. In 1999–2000, 2001–2002, and 2003–2004, statins were being used by 19.6%, 27.3%, and 35.9% of US adults with high LDL-C levels, respectively (p trend <0.001). Age-standardized mean LDL-C declined from 119.9 to 112.0 to 100.7 mg/dL among statin users between 1999–2000, 2001–2002, and 2003–2004. LDL-C control to ATP-III recommended targets was achieved by 49.7%, 67.4%, and 77.6% of statin users in 1999–2000, 2001–2002, and 2003–2004, respectively (p trend <0.001). Among US adults with high LDL-C, after multivariate adjustment, non-Hispanic blacks were 39% less likely (prevalence ratio = 0.61; 95 CI 0.39 to 0.97) than non-Hispanic whites to be taking statins.

CONCLUSIONS: Statin use continues to increase among US adults and this has led to substantial improvements in LDL-C control. Nevertheless, suboptimal statin use, especially among racial/ethnic minorities, continues to prevent the maximal public health benefit from this effective drug class.

Key Words: low-density lipoprotein cholesterol, National Cholesterol Education Program Third Adult Treatment Panel, statins

Published Online, July 23, 2008. www.theannals.com, DOI 10.1345/aph.1L181


This article has been cited by other articles:


Home page
JCOHome page
G. S. Nowakowski, M. J. Maurer, T. M. Habermann, S. M. Ansell, W. R. Macon, K. M. Ristow, C. Allmer, S. L. Slager, T. E. Witzig, and J. R. Cerhan
Statin Use and Prognosis in Patients With Diffuse Large B-Cell Lymphoma and Follicular Lymphoma in the Rituximab Era
J. Clin. Oncol., January 20, 2010; 28(3): 412 - 417.
[Abstract] [Full Text] [PDF]


Home page
LupusHome page
L. Scalzi, S. Bhatt, R. Gilkeson, and M. Shaffer
The relationship between race, cigarette smoking and carotid intimal medial thickness in systemic lupus erythematosus
Lupus, December 1, 2009; 18(14): 1289 - 1297.
[Abstract] [PDF]


Home page
JAMAHome page
E. V. Kuklina, P. W. Yoon, and N. L. Keenan
Trends in High Levels of Low-Density Lipoprotein Cholesterol in the United States, 1999-2006
JAMA, November 18, 2009; 302(19): 2104 - 2110.
[Abstract] [Full Text] [PDF]


Home page
Circ Cardiovasc Qual OutcomesHome page
F. Lopez-Jimenez, J. A. Batsis, V. L. Roger, L. Brekke, H. H. Ting, and V. K. Somers
Trends in 10-Year Predicted Risk of Cardiovascular Disease in the United States, 1976 to 2004
Circ Cardiovasc Qual Outcomes, September 1, 2009; 2(5): 443 - 450.
[Abstract] [Full Text] [PDF]


Home page
ANN INTERN MEDHome page
S. Y. Angell, L. D. Silver, G. P. Goldstein, C. M. Johnson, D. R. Deitcher, T. R. Frieden, and M. T. Bassett
Cholesterol Control Beyond the Clinic: New York City's Trans Fat Restriction
Ann Intern Med, July 21, 2009; 151(2): 129 - 134.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
M. M. Robinson, K. L. Hamilton, and B. F. Miller
The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise
J Appl Physiol, July 1, 2009; 107(1): 8 - 16.
[Abstract] [Full Text] [PDF]


Home page
JAMAHome page
H. D. Sesso and J. M. Gaziano
Antioxidant Supplements and Cardiovascular Disease in Men--Reply
JAMA, April 1, 2009; 301(13): 1336 - 1337.
[Full Text] [PDF]




homecopy help contact us subscription past issues search current issue
Copyright © 2008 by Harvey Whitney Books Company.