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Published Online, 18 March 2009, www.theannals.com, DOI 10.1345/aph.1L614.
 The Annals of Pharmacotherapy: Vol. 43, No. 4, pp. 596-602. DOI 10.1345/aph.1L614
© 2009 Harvey Whitney Books Company.
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CARDIOLOGY

Effect of "Energy Drink" Consumption on Hemodynamic and Electrocardiographic Parameters in Healthy Young Adults

Leah Steinke, PharmD Student

Wayne State University, Detroit, MI

David E Lanfear, MD FACC

Senior Staff Cardiologist, Division of Cardiology, Henry Ford Hospital, Detroit

Vishnuprabha Dhanapal, PharmD

PGY1 Pharmacy Resident, Deparment of Pharmacy Services, Henry Ford Hospital

James S Kalus, PharmD BCPS (AQ CV)

Senior Manager, Patient Care Services, Henry Ford Hospital

Reprints: Dr. Kalus, Department of Pharmacy Services, Henry Ford Hospital, 2799 W. Grand Blvd., Detroit, MI 48202, fax 313/916-1302, jkalus1{at}hfhs.org

BACKGROUND: Energy drinks are frequently purported to improve cognitive function and concentration. However, the cardiovascular effects of these drinks have not been adequately studied.

OBJECTIVE: To determine the cardiac effects of a commercially available, multicomponent energy drink in healthy volunteers.

METHODS: Fifteen healthy adults were included in this prospective study. Individuals who had chronic medical conditions, were on chronic medication, or were pregnant or breast-feeding were excluded. Subjects abstained from caffeine for 48 hours prior to and during the study. In the morning on Day 1 of the study, while subjects were in a fasted state, baseline blood pressure (BP), heart rate (HR), and electrocardiographic (ECG) parameters were measured. Participants then consumed 500 mL (2 cans) of an energy drink and measurements were repeated 30 minutes, 1 hour, 2 hours, 3 hours, and 4 hours later. Participants then drank 500 mL of energy drink daily for the next 5 days. Day 1 protocol was repeated on Day 7.

RESULTS: On Days 1 and 7, maximum mean systolic BP (SBP), HR, and QTc interval occurred at 4 hours. Maximum diastolic BP (DBP) occurred at 2 hours on Days 1 and 7. Within 4 hours of energy drink consumption, on Days 1 and 7, respectively, SBP increased by 7.9% (p = 0.006) and 9.6% (p < 0.001), HR increased by 7.8% (p = 0.009) and 11.0% (p < 0.001), and QTc interval increased by 2.4% (p = 0.368) and 5.0% (p = 0.052). DBP increased by 7.0% (p = 0.046) and 7.8% (p = 0.063) within 2 hours of energy drink consumption on Days 1 and 7, respectively.

CONCLUSIONS: Although no significant ECG changes were observed, HR increased 5-7 beats/min and SBP increased 10 mm Hg after energy drink consumption.

Key Words: blood pressure, electrocardiogram, energy drink, heart rate

Published Online, March 18, 2009. www.theannals.com, DOI 10.1345/aph.1L614




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