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ANTICOAGULATION

Clinical Outcomes and Pharmacists' Acceptance of a Community Hospital's Anticoagulation Management Service Utilizing Decentralized Clinical Staff Pharmacists

Assistant Professor, Department of Clinical Pharmacy, The University of Tennessee College of Pharmacy, Knoxville Campus, Knoxville, TN

Alexander B Guirguis, PharmD BCPS

Assistant Professor, Department of Clinical Pharmacy, The University of Tennessee College of Pharmacy, Knoxville Campus

Rima A Mohammad, PharmD BCPS

Assistant Professor, Department of Pharmacy Practice, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, New York, NY

Reprints: Dr. Airee, The University of Tennessee College of Pharmacy, Knoxville Campus, 1924 Alcoa Hwy., Box 117, Knoxville, TN 37920, fax 865/974-2022, aairee{at}utmem.edu

BACKGROUND: In 2008, the Joint Commission released an updated National Patient Safety Goals document that requires institutions to implement practices that reduce the likelihood of patient harm associated with use of anticoagulation therapy. One of the expectations associated with this goal was that each organization would establish an anticoagulant management program. To our knowledge, few data exist to describe the implementation and assessment of anticoagulation programs in smaller, nonteaching community hospitals using decentralized pharmacists in an integrated practice model.

OBJECTIVE: To compare the performance of a protocol-driven anticoagulation management service led by decentralized pharmacists in a nonteaching community hospital with that of usual medical care provided by hospitalist physicians before this program was implemented. Based on these results, as well as a pharmacist satisfaction survey, evaluate the service and identify barriers to expansion.

METHODS: We conducted a retrospective cohort study comparing 50 consecutive patients who were starting warfarin for the first time beginning in November 2003 with 50 patients managed by hospitalist physicians prior to November 2002 (the time of program implementation).

RESULTS: There were no significant differences between groups with regard to time in therapeutic range once therapeutic, length of stay, international normalized ratios (INRs) greater than 3.5, or INRs less than 2. Patients in the pharmacy management group had significantly fewer drug interactions with antimicrobials than did the usual medical care group. Although time to therapeutic range was longer in the pharmacy protocol group, there were fewer patients with INRs greater than 3.5, although this did not reach statistical significance.

CONCLUSIONS: The efficacy of the pharmacist-led anticoagulation management service was no different from that of usual medical care. Patient safety appeared improved, in part due to more careful initial dose selection based on patient-specific factors. Although this program was accepted by pharmacists, time limitations were perceived to be a major barrier to quality care and expansion of the service.

Key Words: anticoagulation, nonteaching community hospital, pharmacist, protocol, warfarin

Published Online, March 24, 2009. www.theannals.com, DOI 10.1345/aph.1L460