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Published Online, 10 March 2009, www.theannals.com, DOI 10.1345/aph.1L483.
The Annals of Pharmacotherapy: Vol. 43, No. 4, pp. 740-744. DOI 10.1345/aph.1L483
© 2009 Harvey Whitney Books Company.
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Human Papillomavirus Quadrivalent Vaccine: A Look Behind The Numbers

Dennis K Flaherty, PhD

Associate Professor, Department of Pharmaceutical and Administrative Sciences, School of Pharmacy, University of Charleston, Charleston, WV

Fadi M Alkhateeb, PhD

Assistant Professor, Department of Pharmaceutical and Administrative Sciences, School of Pharmacy, University of Charleston

Reprints: Dr. Flaherty, University of Charleston School of Pharmacy, 2300 MacCorkle Ave., SE, Charleston, WV 25304, fax 304/357-4868, dennisflaherty{at}ucwv.edu

Abstract

The human papillomavirus (HPV) quadrivalent vaccine was licensed in 2006 for prevention of cervical, vulvar, and vaginal cancers caused by HPV-16 and -18 and genital warts caused by HPV-6 and -11. It is also indicated for prevention of precancerous and dysplastic lesions caused by HPV-6, -11, -16, and -18. Questions exist about the number of women and girls infected with the HPV strains covered by the vaccine, as well as about the vaccine's cost-effectiveness. There are also concerns about the efficacy of the vaccine in girls and young women, the population impact of the vaccine, the duration of protection, and the usefulness of the vaccine in developing countries. Careful consideration should be given to these issues by pharmacy and pharmacy professional organizations. To formulate reasonable healthcare guidelines, pharmacists and other healthcare professionals will need to engage policymakers in conversations concerning the vaccine's merits or limitations and the economic impact.

Key Words: cervical cancer, Gardasil, human papillomavirus, vaccine

Published Online, March 10, 2009. www.theannals.com, DOI 10.1345/aph.1L483





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