The Annals Evolution of Clinical Pharmacy | Now Available
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     


Published Online, 18 March 2009, www.theannals.com, DOI 10.1345/aph.1L527.
 The Annals of Pharmacotherapy: Vol. 43, No. 4, pp. 772-776. DOI 10.1345/aph.1L527
© 2009 Harvey Whitney Books Company.
This Article
Right arrow Résumé Freely available
Right arrow Extracto Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Southward, J.
Right arrow Articles by Rabinovich, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Southward, J.
Right arrow Articles by Rabinovich, M.

Probable Amlodipine-Induced Angioedema

Jessica Southward, PharmD

Postgraduate Year 2 Emergency Medicine Specialty Resident, Pharmacy and Drug Information, Grady Health System, Atlanta, GA

Elizabeth Irvine, PharmD

Postgraduate Year 2 Hematology/Oncology Specialty Resident, Pharmacy and Drug Information, Grady Health System

Marina Rabinovich, PharmD BCPS

Critical Care Specialist, Pharmacy and Drug Information, Grady Health System

Reprint: Dr. Southward, Pharmacy and Drug Information, Grady Health System, 80 Jesse Hill Jr. Dr., SE, Atlanta, GA 30303, fax 404/616-2228, jsouthward{at}gmh.edu

OBJECTIVE: To report a case of angioedema likely associated with amlodipine administration in a patient with a right thalamic hemorrhagic stroke.

CASE SUMMARY: A 50-year-old female experienced angioedema during hospitalization for a right thalamic hemorrhagic stroke. She had no past history of angioedema and all of her medications were assessed for risk of angioedema. After careful evaluation, case reports linking calcium channel blockers (CCBs) and angioedema led to further examination of amlodipine as a cause. Amlodipine therapy had been initiated 24 hours prior to the development of angioedema, which then resolved 72 hours after discontinuation of the drug. In total, the patient experienced oropharyngeal swelling for 10 days.

DISCUSSION: In determining a cause for the patient's angioedema we eliminated genetic, allergic, physically induced, thyroid autoimmune disease-associated, and medication-induced causes. Three case reports describing 7 patients have linked the CCBs verapamil, diltiazem, and nifedipine with angioedema. The onset and resolution of symptoms in our patient were very similar to those seen in other case reports. Application of the Naranjo probability scale found a probable link between amlodipine and angioedema.

CONCLUSIONS: Although few reports of CCB-induced angioedema exist, to our knowledge, this is the first reported case to suggest a link between angioedema and amlodipine therapy. Clinicians should consider amlodipine as a potential cause of angioedema.

Key Words: amlodipine, angioedema, calcium-channel blocker

Published Online, March 18, 2009. www.theannals.com, DOI 10.1345/aph.1L527




homecopy help contact us subscription past issues search current issue
Copyright © 2009 by Harvey Whitney Books Company.