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GERIATRICS

Targeting Suboptimal Prescribing in the Elderly: A Review of the Impact of Pharmacy Services

PhD Candidate, Faculty of Pharmacy, The University of Sydney, Australia

Beata V Bajorek, BPharm Dip Hosp Pharm PhD

Lecturer in Pharmacy Practice, Faculty of Pharmacy, The University of Sydney

Timothy F Chen, BPharm Dip Hosp Pharm PhD

Senior Lecturer in Pharmacy Practice, Faculty of Pharmacy, The University of Sydney

Reprints: Mr. Castelino, Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia, fax 0061 2 9351 4391, rcas6711{at}usyd.edu.au

OBJECTIVE: To review the currently available literature on the impact of interventions by pharmacists on suboptimal prescribing in the elderly.

DATA SOURCES: MEDLINE, EMBASE, and International Pharmaceutical Abstracts databases were searched for studies published between January 1992 and December 2008. Key words included medication review, drug regimen review, pharmaceutical services, pharmaceutical care, pharmacists, medications, appropriateness, suboptimal, underuse, aged, elderly, randomized controlled trial, inappropriate, prescribing, and intervention.

STUDY SELECTION AND DATA EXTRACTION: To be included in the review, studies must have been conducted in patients 65 years or older, published in English, randomized and controlled, and must have included an intervention delivered by a pharmacist or had a pharmacist as a member of the intervention team. From each relevant study, the following data were extracted: study duration, country, number of patients, year of publication, objective, type and impact of the intervention, method used to assess suboptimal prescribing, and data concerning the quality of the study.

DATA SYNTHESIS: A total of 38 articles were identified, of which 12 matched our inclusion criteria. Seven articles included interventions initiated by pharmacists, and the remaining 5 described interventions in which the pharmacist was a part of the multidisciplinary team. A broad range of tools was used to measure prescribing appropriateness; we found that a consensus on the best approach has not been reached. Most of the studies involving pharmacists showed significant improvement in suboptimal prescribing at one or more time points. However, most of these interventions were directed toward reducing the overuse or misuse of medications.

CONCLUSIONS: Pharmacy services to reduce suboptimal prescribing have shown promising and noteworthy improvements. More research is needed to address the underutilization of medications in the elderly and healthcare impact of reducing suboptimal prescribing.

Key Words: elderly, inappropriate prescribing, pharmacist interventions

Published Online, May 26, 2009. www.theannals.com, DOI 10.1345/aph.1L700