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The Annals of Pharmacotherapy: Vol. 37, No. 3, pp. 442-446. DOI 10.1345/aph.1C277
© 2003 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

OBJECTIF: Évaluer l'effet des inhibiteurs sélectifs de la cyclooxygénase-2 (ICOX-2) sur la tension artérielle (TA).

SOURCE DE L'INFORMATION: Toutes les publications retrouvées lors d'une recherche sur MEDLINE avec les mots-clés suivants: inhibiteurs sélectifs COX-2, agents anti-inflammatoires, non-stéroidiens, celecoxib, rofecoxib, et hypertension.

SYNTHÈSE DE L'INFORMATION: Les données sur les effets des ICOX-2 sur la TA dans les études prospectives sont conflictuelles. Plusieurs études ont rapporté que l'augmentation de la TA était un effet indésirable des ICOX-2.

CONCLUSION: Des études supplémentaires sont requises pour évaluer adéquatement l'effet des ICOX-2 sur la TA. En attendant, les ICOX-2 devraient être utilisés avec précaution chez les patients hypertendus et la TA devrait être suivie étroitement si ces médicaments étaient utilisés.




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J. Wang, C D. Mullins, M. Mamdani, D. A Rublee, and F. T Shaya
New Diagnosis of Hypertension Among Celecoxib and Nonselective NSAID Users: A Population-Based Cohort Study
Ann. Pharmacother., June 1, 2007; 41(6): 937 - 943.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
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Right arrow For Our Patients
Right arrow Alert me when this article is cited
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Right arrow Articles by Johnson, D. L
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Right arrow Articles by Johnson, D. L
Right arrow Articles by Phillips, B. B.

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Copyright © 2003 by Harvey Whitney Books Company.