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The Annals of Pharmacotherapy: Vol. 37, No. 5, pp. 687-694. DOI 10.1345/aph.1C297
© 2003 Harvey Whitney Books Company.
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OBJECTIF: Faire le point sur la pharmacologie, la pharmacocinétique, l'efficacité clinique, et le profil de sécurité de l'aripiprazole dans le traitement de la schizophrénie.

SOURCES DE DONNEES: Information extraite de PubMed (janvier 1995–août 2002). Des résumés, posters, et communications scientifiques ont également été utilisés.

SYNTHESES DES DONNEES: L'aripiprazole est un agoniste partiel de la dopamine et un antagoniste des récepteurs de la sérotonine (5-HT2A), prescrit à la dose de 10 à 30 mg/j, sans phase de titration. Les essais cliniques sur des périodes courtes démontrent une efficacité sur les exacerbations aiguës, et les essais à long terme un maintien des rémissions. La plupart des événements indésirables sont de peu de gravité. L'incidence des symptômes extrapyramidaux est faible, l'akathisie étant le plus courant.

CONCLUSIONS: L'aripiprazole démontre actuellement à la fois efficacité et sécurité dans son utilisation pour la schizophrénie.




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This Article
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Citing Articles
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Google Scholar
Right arrow Articles by Bowles, T. M
Right arrow Articles by Levin, G. M
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Right arrow PubMed Citation
Right arrow Articles by Bowles, T. M
Right arrow Articles by Levin, G. M

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Copyright © 2003 by Harvey Whitney Books Company.