The Annals Holiday Offer - Save 50%
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     

The Annals of Pharmacotherapy: Vol. 37, No. 9, pp. 1325-1328. DOI 10.1345/aph.1C412
© 2003 Harvey Whitney Books Company.
This Article
Right arrow Abstract Freely available
Right arrow Extracto Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fulco, P. P.
Right arrow Articles by Kirian, M. A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fulco, P. P.
Right arrow Articles by Kirian, M. A

DRUG INFORMATION ROUNDS

OBJECTIF: Evaluer l'interaction pharmacocinétique entre le ténofovir et la didanosine employés en association antirétrovirale de haute efficacité.

REVUE DE LITTÉRATURE: Littérature repérée par une recherche sur MEDLINE (1966 à janvier 2003; mots-clés: ténofovir, didanosine). Les résumés de congrès récents, notamment ceux de la Société internationale du SIDA, de la Conférence internationale sur les agents antimicrobiens et la chimiothérapie (ICAAC), et de la Société américaine d'infectiologie, ont aussi été exploités.

RÉSUMÉ: Le ténofovir est autorisé dans le traitement de l'infection par le VIH en association avec d'autres agents antirétroviraux. L'interaction entre le ténofovir et la didanosine a été évaluée pour déterminer la sécurité de cette association.

CONCLUSIONS: Le ténofovir augmente significativement les concentrations plasmatiques et l'aire sous la courbe de la didanosine chez des volontaires sains. Des données supplémentaires sont nécessaires pour déterminer le mécanisme de cette interaction et la toxicité à long terme de cette association. Une réduction des doses de didanosine devrait être envisagée lorsque ces 2 médicaments sont employés concomitamment chez des patients infectés par le VIH.




This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
A. Pruvost, E. Negredo, F. Theodoro, J. Puig, M. Levi, R. Ayen, J. Grassi, and B. Clotet
Pilot Pharmacokinetic Study of Human Immunodeficiency Virus-Infected Patients Receiving Tenofovir Disoproxil Fumarate (TDF): Investigation of Systemic and Intracellular Interactions between TDF and Abacavir, Lamivudine, or Lopinavir-Ritonavir
Antimicrob. Agents Chemother., May 1, 2009; 53(5): 1937 - 1943.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
F. Vidal, J. C. Domingo, J. Guallar, M. Saumoy, B. Cordobilla, R. Sanchez de la Rosa, M. Giralt, M. L. Alvarez, M. Lopez-Dupla, F. Torres, et al.
In Vitro Cytotoxicity and Mitochondrial Toxicity of Tenofovir Alone and in Combination with Other Antiretrovirals in Human Renal Proximal Tubule Cells
Antimicrob. Agents Chemother., November 1, 2006; 50(11): 3824 - 3832.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
P. Barreiro and V. Soriano
Suboptimal CD4 gains in HIV-infected patients receiving didanosine plus tenofovir
J. Antimicrob. Chemother., May 1, 2006; 57(5): 806 - 809.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. Pruvost, E. Negredo, H. Benech, F. Theodoro, J. Puig, E. Grau, E. Garcia, J. Molto, J. Grassi, and B. Clotet
Measurement of Intracellular Didanosine and Tenofovir Phosphorylated Metabolites and Possible Interaction of the Two Drugs in Human Immunodeficiency Virus-Infected Patients
Antimicrob. Agents Chemother., May 1, 2005; 49(5): 1907 - 1914.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
M. A Kirian, R. T Higginson, and P. P. Fulco
Acute Onset of Pancreatitis with Concomitant Use of Tenofovir and Didanosine
Ann. Pharmacother., October 1, 2004; 38(10): 1660 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. S. Ray, L. Olson, and A. Fridland
Role of Purine Nucleoside Phosphorylase in Interactions between 2',3'-Dideoxyinosine and Allopurinol, Ganciclovir, or Tenofovir
Antimicrob. Agents Chemother., April 1, 2004; 48(4): 1089 - 1095.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Extracto Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fulco, P. P.
Right arrow Articles by Kirian, M. A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fulco, P. P.
Right arrow Articles by Kirian, M. A

homecopy help contact us subscription past issues search current issue
Copyright © 2003 by Harvey Whitney Books Company.