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Published Online, 30 April 2004, www.theannals.com, DOI 10.1345/aph.1D166.
 The Annals of Pharmacotherapy: Vol. 38, No. 6, pp. 1060-1064. DOI 10.1345/aph.1D166
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

OBJECTIF: Réviser les éléments de preuve pour l'emploi des statines en prévention secondaire chez les patients coronariens ayant des valeurs de LDL-cholestérol optimales ou sub-optimales.

REVUE DE LITTÉRATURE: Littérature repérée sur MEDLINE (1966 à Octobre 2003). Mots-clés: inhibiteurs de l'HMG-CoA réductase, statines, maladie coronarienne, post-infarctus du myocarde, et cholestérol.

RÉSUMÉ: Les essais de prévention secondaire incluant des sujets avec des valeurs de LDL-cholestérol optimales (<130 mg/dL) ou sub-optimales (<100 mg/dL) ont été examinés. Les premières études de prévention secondaire suggéraient un bénéfice moindre mais des essais plus récents remettent en cause cette conclusion.

CONCLUSIONS: L'emploi de statines en prévention secondaire chez des patients coronariens ayant des valeurs de LDL-cholestérol proches des valeurs cibles est controversée, mais des essais récents montrent des résultats encourageants.

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