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Published Online, 8 June 2004, www.theannals.com, DOI 10.1345/aph.1D486.
 The Annals of Pharmacotherapy: Vol. 38, No. 7, pp. 1222-1225. DOI 10.1345/aph.1D486
© 2004 Harvey Whitney Books Company.
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OBJECTIF: Rapporter un cas de rhabdomyolyse causé par le Commiphora mukul.

RÉSUMÉ: Un homme de 55 ans a pris un extrait de C. mukul pour réduire son cholestérol. Il a développé par la suite une rhabdomyolyse avec hémoglobinurie après un traitement de 2 semaines. Les tests de laboratoire indiquaient les valeurs suivantes: créatinine phosphokinase 144 600 IU/L (normale 24–195), myoglobine >3000 ng/mL (28–72), lactate déshydrogénase 7157 UI/L (230–460), AST 1115 IU/L (10–35), et ALT 205 UI/L (10–35). L'analyse d'un échantillon urinaire a démontré la présence de hémoglobine 2+. Tous les paramètres sont redevenus normaux après l'arrêt du produit naturel.

DISCUSSION: La probabilité de Naranjo indique le C. mukul comme étant la cause possible de rhabdomyolyse chez ce patient. Cet effet secondaire est bien connu lorsque de hautes doses de statines ou lorsqu'une statine est combinée à un fibrate. Ce cas est le premier rapporté de rhabdomyolyse secondaire à C. mukul, un agent hypolipémiant naturel.

CONCLUSIONS: Notre rapport décrit un cas de rhabdomyolyse possiblement causé par le C. mukul et fait réaliser le besoin de surveillance des produits naturels.

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Copyright © 2004 by Harvey Whitney Books Company.