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Published Online, 13 July 2004, www.theannals.com, DOI 10.1345/aph.1D632.
 The Annals of Pharmacotherapy: Vol. 38, No. 9, pp. 1525-1528. DOI 10.1345/aph.1D632
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

OBJECTIF: Réviser la littérature relative aux faux-positifs associés à l'emploi de fluoroquinolones lors du dépistage urinaire des opiacés.

REVUE DE LITTÉRATURE: Littérature repérée par des recherches sur MEDLINE (1966 à février 2004), EMBASE, et l'ensemble des Revues de médecine factuelle (EBM Reviews). Mots-clés: quinolones, détection de substances donnant lieu à abus, opiacés, réactions croisées, faux-positifs, et chacune des fluoroquinolones. Les références des articles ont aussi été examinées.

RÉSUMÉ: Deux études ont montré que des fluoroquinolones interféraient avec certains immuno-essais employés dans le dépistage urinaire des opiacés au seuil de 300 µg/L de morphine. Le m écanisme d'interaction n'a pas été élucidé.

CONCLUSIONS: Des fluoroquinolones peuvent entraîner des faux-positifs dans les dépistages urinaires d'opiacés. Les cliniciens devraient être attentifs à cette interaction potentielle et devraient vérifier les résultats positifs.

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Copyright © 2004 by Harvey Whitney Books Company.